In this paper we numerically investigate drop impact on a micro-well substrate to understand the phenomena of non-wettability. The simulation is carried out by solving the three-dimensional incompressible Navier-Stokes equations using the density projection method and adaptive grid refinement algorithm. A very sharp interface reconstruction algorithm, known as the moment-of-fluid (MOF) method, is utilized to identify the multi-materials and multi-phases present in the computation domain. Our simulations predicted that a micro-well with a deep cavity can significantly reduce solid-liquid contact in the event of a drop impact. Results from the drop impact on the micro-well substrate are compared with results from a drop impact on a flat substrate. Significant differences are observed between these two cases in terms of wetted area, spreading ratio and kinetic energy. Our simulation shows that under the same conditions, a drop is more apt to jump from a micro-well substrate than from a flat surface, resulting in smaller wetted area and shorter contact time. Based on the simulation results we draw a drop jumping region map. The micro-well substrate has a larger region than the flat surface substrate. Lastly, we present a comparative analysis between a flat substrate and a substrate constructed with a dense array of micro-wells and therefore show that the array of micro-wells outperforms smooth substrate with regards to non-wettability and the drop wicking capability.