A Novel Surface Structure Consisting of Contact-active Antibacterial Upper-layer and Antifouling Sub-layer Derived from Gemini Quaternary Ammonium Salt Polyurethanes

He, Wei; Zhang, Yi; Li, Jiehua; Gao, Yunlong; Luo, Feng; Tan, Hong; Wang, Kunjie; Fu, Qiang

doi:10.1038/srep32140

Cited by 77 publications

(73 citation statements)

References 46 publications

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“…Examples of agents which are mostly used in biocide release antimicrobial coatings are silver ions, triclosan, chlorhexidine, chlorine, tributyltin, nitric oxide, and antibiotics [54]. A commonly studied example of contact active biocidal agent is quaternary ammonium compounds [55, 56]. It is important to note here that some of the biocidal mechanisms of different agents can overlap (e.g.…”

Section: Introductionmentioning

confidence: 99%

A review of the recent advances in antimicrobial coatings for urinary catheters

2017

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More than 75% of hospital-acquired or nosocomial urinary tract infections are initiated by urinary catheters, which are used during the treatment of 15–25% of hospitalized patients. Among other purposes, urinary catheters are primarily used for draining urine after surgeries and for urinary incontinence. During catheter-associated urinary tract infections, bacteria travel up to the bladder and cause infection. A major cause of catheter-associated urinary tract infection is attributed to the use of non-ideal materials in the fabrication of urinary catheters. Such materials allow for the colonization of microorganisms, leading to bacteriuria and infection, depending on the severity of symptoms. The ideal urinary catheter is made out of materials that are biocompatible, antimicrobial, and antifouling. Although an abundance of research has been conducted over the last forty-five years on the subject, the ideal biomaterial, especially for long-term catheterization of more than a month, has yet to be developed. The aim of this review is to highlight the recent advances (over the past 10 years) in developing antimicrobial materials for urinary catheters and to outline future requirements and prospects that guide catheter materials selection and design.

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Section: Introductionmentioning

confidence: 99%

A review of the recent advances in antimicrobial coatings for urinary catheters

2017

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“…Besides lowering surface tension, gemini surfactants have some exceptional properties which include low cmc value, high surface activity, etc. 11,12 .…”

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confidence: 99%

Kinetic study of the metal-dipeptide complex with ninhydrin facilitated by gemini (m-s-m) surfactant micelles

Azum

Kumar

2020

Sci Rep

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the three Gemini (m-s-m; m (head group) = 16 and s (spacer) = 4, 5, 6) surfactants have been synthesized and their impact on reaction of zinc(ii)-glycylleucine complex ([Zn(ii)-Gly-Leu] +) and ninhydrin were studied at temperature (343 K) and pH (5.0) using spectroscopic method. Influence of several factors, viz., [Zn(II)-Gly-Leu] + , [ninhydrin], temperature and pH were also carried out on title reaction in geminis. Rates of reaction are the first-order path in concentration of [Zn(II)-Gly-Leu] + complex and fractional order path in concentration of ninhydrin. The catalysis of gemini 16-s-16 surfactant micelles was investigated below and above their critical micelle concentration (cmc) value and detailed elaboration were provided in the text. In the present case, rate constants, k ψ , increased on increasing geminis ([gemini] are below their cmc, region I) and stayed nearly constant (region II). The shape of (region I and II) surfactants ([gemini] = 0 to 400 × 10 −5 mol dm −3) are similar to a cetyltrimethylammonium bromide, CTAB (single hydrophilic head group and hydrophobic part). Later, a sharp increment in rate was observed with higher [gemini] (region III, (Fig. 5). The study was catalyzed and accelerated quite enough by geminis (at concentrations below their cmc) compared to aqueous. An appropriate mechanism has been proposed for accounting for the distribution of reactants between aqueous and micellar pseudo phases. Resulting kinetic data were used to determine the binding constants of micelle-substrate (K B) and micelle-ninhydrin (K nin).

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“…The Therefore, these results demonstrated that the mechanism of action of these antimicrobial surfaces is by cell-membrane disrupting due to hydrophobic interactions and electrostatic interactions between the negatively charged cell walls and the positively charged copolymers [24][25][26][27] .…”

Section: Evaluation Of the Morphological Changes Of Microbesmentioning

confidence: 99%

Tailoring Macromolecular Structure of Cationic Polymers towards Efficient Contact Active Antimicrobial Surfaces

Tejero¹,

Gutiérrez²,

López³

et al. 2018

Preprint

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The aim of this work is the preparation of contact active antimicrobial films by blending copolymers with quaternary ammonium salts and polyacrylonitrile as matrix material. A series of copolymers based on acrylonitrile and methacrylic monomers with quaternizable groups were designed with the purpose of investigating the influence of their chemical and structural characteristics on the antimicrobial activity of these surfaces. The biocide activity of these systems was studied against different microorganisms, such as the Gram-positive bacteria Staphylococcus aureus and the Gram-negative bacteria Pseudomona aeruginosa and the yeast Candida parapsilosis. The results confirmed that parameters such as flexibility and polarity of the antimicrobial polymers immobilized on the surfaces strongly affect the efficiency against microorganisms. In contrast to the behavior of copolymers in water solutions, when they are tethered to the surface, the active cationic groups are less accessible and then the mobility of the side chain is critical for a good contact with the microorganism. Blend films composed of copolymers with high positive charge density and chain mobility present up to a more than 99.999% killing efficiency against the studied microorganisms.Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted:

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A Novel Surface Structure Consisting of Contact-active Antibacterial Upper-layer and Antifouling Sub-layer Derived from Gemini Quaternary Ammonium Salt Polyurethanes

Cited by 77 publications

References 46 publications

A review of the recent advances in antimicrobial coatings for urinary catheters

A review of the recent advances in antimicrobial coatings for urinary catheters

Kinetic study of the metal-dipeptide complex with ninhydrin facilitated by gemini (m-s-m) surfactant micelles

Tailoring Macromolecular Structure of Cationic Polymers towards Efficient Contact Active Antimicrobial Surfaces

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