A Novel Synthesis of New 1,8‐Naphthyridine Derivatives Using the Reaction of Vinamidinium Salts With 2,6‐Diaminopyridine

Abstract

Some new substituted 1,8‐ naphthyridines 2a, 2b, 2c, 2d, 2e, 2f, 2g have been synthesized by treating various 2‐substituted vinamidinium salts 1a, 1b, 1c, 1d, 1e, 1f, 1g with 2,6‐diaminopyridine. The structures of the synthesized compounds have been established on the basis of elemental analysis and spectroscopic data (1H‐NMR, 13C‐NMR, IR, UV/VIS, and mass).

Synthesis and characterization of new derivatives of bis(1,4‐diazepinium) salts and bis(γ‐substituted pentamethine cyanine(dyes using vinamidinium salt

“…These salts are generated from an acetic acid derivative, utilizing Vilsmeier‐Haack‐Arnold formylation as described in our previous works . 1,4‐Diazepines derivatives are commonly used as painkillers, sedatives, antidepressants and hypnotics . The development of an efficient and simple process for the preparation of these compounds is of great importance because of numerous pharmacological actions and industrial uses …”

Trifluoromethyl Vinamidinium Salt as a Promising Precursor for Fused β-Trifluoromethyl Pyridines

“…Therefore, we decided to elaborate a new method based on the Combes-type reaction of heteroaromatic amines 5 , which were considered DOS-related substrates, and trifluoromethyl vinamidinium salt 8 . This approach was previously known from the literature for various vinamidinium salts and their analogues, which introduced different substituents in the β-position of fused pyridine rings, e.g., aryl, fluorine, bromine, nitro, nitrile, aldehyde, and arylsulfonyl . Particularly, we obtained sets of compounds types 3 and 4 based on the reactions with electron-rich aminoheterocycles and synthetic equivalents of functionalized malonic dialdehyde. , Furthermore, during that projects, we established a set of diverse aminoheterocycles, which can be used as models in such heterocyclizations .…”