A Novel Synthesis of Thieno[2,3-C]pyrazole

Synthesis, reactions, and spectral characterization of some new biologically active compounds derived from thieno[2,3‐c]pyrazole‐5‐carboxamide

“…starting from 5‐chloro‐3‐methyl‐1‐phenyl‐1 H ‐pyrazole‐4‐carbaldehyde ( 8) by the reaction with formaldehyde, diethyl dithioacetal S‐oxide (FAESO) in THF in the presence of NaH followed by treatment with alcohol and HCl. Then stirring of the carboxylic acid formed with CS 2 and KOH in DMSO overnight at room temperature followed by addition of alkyl halide yielded the ring‐closed thieno[2,3‐ c ]pyrazoles . Cyclocondensation of the amino‐carboxamide 1 with diethyl malonate in boiling acetic acid afforded the ethyl pyrazolothienopyrimidinyl acetate 2 .…”

5-Chloropyrazole-4-carboxaldehydes as synthon in heterocyclic synthesis

“…Compound 228 was prepared via treatment of 4 with FAESO in NaH/THF, which was then converted to compounds 230 via bubbling HCl gas through a solution of 228 in methanol or ethanol 229. Compounds 230 were stirred with CS 2 , KOH and DMSO then alky halide R 0 X was added to give the ring-closed products 232a-c (Scheme 48) [76].…”

Indium‐mediated facile preparation of 2‐(heterocyclic thio)‐1‐(2,3,4‐trimethoxyphenyl)ethanone in aqueous media

“…Since then, a number of thioether compounds were synthesized and found to be fungicidal, virucidal, and herbicidal [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. carrying both azole and thioether residues, became of interest for its effectiveness against pathogenic fungi and viruses.…”