2014
DOI: 10.1515/hc-2014-0105
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A novel synthetic approach to 11-substituted dibenzo[b,f][1,4]oxazepines

Abstract: A novel synthetic approach to 11-substituted dibenzo[b,f][1,4]oxazepinesAbstract: A novel protocol for the synthesis of 11-substituted dibenzo [b,f] [1,4]oxazepines is reported. Seven compounds were designed as analogs of the antipsychotic drug loxapine and antidepressant amoxapine. The key transformations include generation of a carbamate intermediate using phenyl chloroformate which avoids the use of harmful phosgene, a microwave-induced transformation of the carbamate intermediate into various urea derivati… Show more

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