A novel tantalum-containing bioglass. Part II. Development of a bioadhesive for sternal fixation and repair

Alhalawani, Adel M.F.; Mehrvar, Cina; Stone, Wendy; Waldman, Stephen D.; Towler, Mark R.

doi:10.1016/j.msec.2016.10.024

Cited by 45 publications

(41 citation statements)

References 61 publications

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“…The Control in the current study showed a higher maximum compressive strength at Day 30 (~30 MPa) compared with that in a similar study published by Alhalawani et al (Alhalawani et al, 2017) (~18 MPa) using a similar glass composition and the same P:L ratio (TA2); likely due to the physicality of the glass phase (the glass particles in this study were sieved to ≤20 μm, whereas in (Alhalawani et al, 2017) they were ≤45 μm, the smaller particle size resulting in a greater surface area available for reaction, leading to a faster setting and increasing strength. From the BFS results, it can be concluded that the incorporation of CaSO 4 does not significantly affect BFS, but increases compressive strength.…”

Section: Discussionsupporting

confidence: 77%

“…Moreover, the bioactive glass systems showed strong antibacterial and antifungal activity against both Gram‐negative and Gram‐positive bacteria. Cytotoxicity results indicated that the resultant GPC is non‐toxic to cells (Alhalawani et al, 2017; Alhalawani & Towler, 2017). The bioactive glass used for this study was prepared by a glass manufacturer (Mo‐Sci, Rolla, MO) using specified fraction (Table 1) according to the paper published by Alhalawani and Towler (2017).…”

Section: Methodsmentioning

confidence: 99%

“…Commercial GPCs for dental restoration, such as Fuji IX GP (GC Europe NV, Leuven, Belgium) and Ketac Cem Easymix (3M ESPE, St. Paul, MN) contain aluminum ions (Al 3+ ) (Kim, Kim, Kim, & Kwon, 2011) that may cause defective bone mineralization (Blades, Moore, Revell, & Hill, 1998; Taïr et al, 2016). To address this issue, the chemistry of GPCs have been modified (Boyd, Clarkin, Wren, & Towler, 2008; Clarkin, Wren, Thornton, Cooney, & Towler, 2011), with elements such as zinc (Zn), strontium (Sr) and tantalum (Ta) added to Al‐free GPCs in an attempt to avoid defective mineralization and impart antibacterial efficiency, biocompatibility, chemical stability and bone regeneration (Alhalawani, Mehrvar, Stone, Waldman, & Towler, 2017; Alhalawani & Towler, 2017; Boyd, Li, Tanner, Towler, & Wall, 2006; Clarkin et al, 2011). The GPC has been shown to bond chemically with bone due to ion exchange at the interface with the mineral phase of bone and the GPC (Khader, Peel, & Towler, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Calcium sulfate‐containing glass polyalkenoate cement for revision total knee arthroplasty fixation

et al. 2020

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Poly(methyl methacrylate) (PMMA) bone cement is used as a minor void filler in revision total knee arthroplasty (rTKA). The application of PMMA is indicated only for peripheral bone defects with less than 5 mm depth and that cover less than 50% of the bone surface. Treating bone defects with PMMA results in complications as a result of volumetric shrinkage, bone necrosis, and aseptic loosening. These concerns have driven the development of alternative bone cements. We report here on novel modified glass polyalkenoate cements (mGPCs) containing 1, 5 and 15 wt% calcium sulfate (CaSO 4) and how the modified cements' properties compare to those of PMMA used in rTKA. CaSO 4 is incorporated into the mGPC to improve both osteoconductivity and bioresorbability. The results confirm that the incorporation of CaSO 4 into mGPCs decreases the setting time and increases release of therapeutic ions such as Ca 2+ and Zn 2+ over 30 days of maturation in deionized (DI) water. Moreover, the compressive strength for 5 and 15 wt% CaSO 4 addition increased to over 30 MPa after 30 day maturation. Although the overall initial compressive strength of the mGPC (~30 MPa) is less than PMMA (~95 MPa), the compressive strength of mGPC is closer to that of cancellous bone (~1.2-7.8 MPa). CaSO 4 addition did not affect biaxial flexural strength. Fourier transform infrared analysis indicated no crosslinking between CaSO 4 and the GPC after 30 days. in vivo tests are required to determine the effects the modified GPCs as alternative on PMMA in rTKA. K E Y W O R D S bone cement, bone loss, calcium sulfate, glass polyalkenoate cement, PMMA, revision total knee arthroplasty 1 | INTRODUCTION Failure of total knee arthroplasty (TKA) requires revision TKA (rTKA) to improve the function of the knee, reduce patient pain and manage both bone loss and infection (Fehring et al., 2008). According to the Canadian Institute for Health Information (CIHI), among 84,770 (35,945, excluding patella) rTKAs performed between 2012 and 2017, main reasons for revision were infection (38.4%), instability (22.7%) and aseptic loosening (16.5%) (Canadian Institute for Health Information, 2018). The bone cement routinely used in rTKA is poly(methyl methacrylate) (PMMA)

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Section: Discussionsupporting

confidence: 77%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Calcium sulfate‐containing glass polyalkenoate cement for revision total knee arthroplasty fixation

et al. 2020

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“…This sudden change, when going from the 650°C of calcination to room temperature, could cause nanoscale defects in the structure. With bulk BGs, these nanoscale defects are sufficient to significantly increase the ion solubility of the glasses in aqueous medium . Therefore, in MBGs, where the channels are just an order of magnitude greater than the defect size, the effect of nanoscale defects is more prominent and causes breaks in the channel structure.…”

Section: Discussionmentioning

confidence: 99%

The effect of tantalum incorporation on the physical and chemical properties of ternary silicon–calcium–phosphorous mesoporous bioactive glasses

et al. 2019

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Synthesis and characterization of the first mesoporous bioactive glasses (MBGs) containing tantalum are reported here, along with their potential application as hemostats. Silica MBGs were synthesized using with the molar composition of (80‐x)% Si, 15% Ca, 5% P, and x% Ta. It was found that incorporation of >1 mol % Ta into the MBGs changes their physical and chemical properties. Increasing Ta content from 0 to 10 mol % causes a decrease in the surface area and pore volume of ~20 and ~35%, respectively. This is due to the increase in nonbridging oxygens and mismatch of thermal expansion coefficient which created discontinuities in the ordered channel structure. However, the effect is not significant on the amount of ions (Si, Ca, P, and Ta) released, from the sample into deionized water, for short durations (<60 min). In a mouse tail‐cut model, a significant decrease in bleeding time (≥50% of average bleeding time) was found for Ta‐MBGs compared to having no treatment, Arista, and MBG without Ta. Further studies are proposed to determine the mechanism of Ta involvement with the hemostatic process. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2229–2237, 2019.

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“…Bioactive glasses can be formulated to deliver therapeutic ions that may bond with bone, initiate remineralization, and provide antibacterial effects [ 14 , 15 , 16 ]. 45S5 Bioglass ® was the first inorganic material designed to bond with bone which did not form scar tissue upon implantation in rat femurs [ 14 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Rapidly-Dissolving Silver-Containing Bioactive Glasses for Cariostatic Applications

Rodriguez

Alhalawani

Arshad

2018

JFB

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A novel bioactive glass series containing incremental amounts of silver oxide was synthesized, ground down, and subsequently incorporated into a dentifrice for the purpose of reducing the incidence of dental caries and lesion formation. Three glasses were synthesized using the melt quench route: Si-Control (70SiO2–12CaO–3P2O5–15Na2O, mol %), Si-02 and Si-05, where 0.2 and 0.5 mol % Ag2O were substituted, respectively, for SiO2 in Si-Control. The glasses were then ground, sieved, characterized, and dissolved in Tris buffer solution (pH = 7.30) for 6, 12, and 24 h, with the pH of the resultant solution being recorded and the ions that were released into solution quantified. Samples of each glass were subsequently embedded into a non-fluoridated, commercially available toothpaste which was then used to brush resin-mounted lamb molars which, up to the point of testing, had been stored in a 1.0 M HCl solution. Knoop microhardness measurements of the molars were recorded before and after brushing to determine the presence of remineralization on the surface of the teeth (surface hardness loss of 37%, 35%, and 34% for Si-Control, Si-02 and Si-05, respectively, after 24 h). Four oral cavity bacterial strains were isolated through swabs of the inner cheek, gums, and teeth surfaces of three volunteers, and placed on agar discs. Of each glass, 0.5 g was placed onto the discs, and the resultant inhibition zones were measured after 6, 12, and 24 h. Si-05 performed better than Si-02 on two strains after 24 h, while exhibiting similar behavior for the remaining two strains after 24 h; the largest inhibition zone measured was 2.8 mm, for Si-05 after 12 h. Si-Control exhibited no antibacterial effect at any time point, providing evidence for the role of silver oxide as the antibacterial component of these glasses.

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A novel tantalum-containing bioglass. Part II. Development of a bioadhesive for sternal fixation and repair

Cited by 45 publications

References 61 publications

Calcium sulfate‐containing glass polyalkenoate cement for revision total knee arthroplasty fixation

Calcium sulfate‐containing glass polyalkenoate cement for revision total knee arthroplasty fixation

The effect of tantalum incorporation on the physical and chemical properties of ternary silicon–calcium–phosphorous mesoporous bioactive glasses

Rapidly-Dissolving Silver-Containing Bioactive Glasses for Cariostatic Applications

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