Due to the difference in oil and water density, the wellhead pressure continues to decrease with water-cut rising in deep-water volatile oilfields. Once it is close to the lower limit, the production well will stop flowing. This phenomenon seriously affects the production and recoverable reserves. By taking the dynamic relative permeability which can reflect the macroscopic movement of oil and water in the reservoir as an intermediate bridge, production performance has been combined with dominant reservoir factors, including reservoir structure, reservoir connectivity, and heterogeneity. By the statistical analysis of actual data, this paper clarified the quantitative relationships between dominant reservoir factors and production performance and established the refined prediction methods for production dynamics including water-cut and liquid production rate. A prediction method for the wellhead pressure was further established, and the flow-stop time of single well can be accurately predicted. The results can be used in annual production forecast and recoverable reserve evaluation. This method had been successfully applied in Akpo oilfields in the Niger Basin. The results show that the production dynamics are significantly affected by reservoir factors in deep-water turbidite sandstone reservoir and the prediction method considering reservoir factors will be much more applicable. In deep-water volatile oilfields, the flow-stop risk of the production well in middle and high water-cut stages is very great and is mainly affected by the water-cut and liquid production rate. Judging from the application effect of Akpo oilfields, this method has high prediction accuracy and can be used to guide optimization and adjustment in deep-water oilfields.