A novel technique of antimicrobial photodynamic therapy – aPDT using 1,9-dimethyl-methylene blue zinc chloride double salt-DMMB and polarized light on Staphylococcus aureus

Santos, Darcy de A.; Crugeira, Pedro J.L.; Nunes, Iago P.F.; Almeida, Paulo Fernando de; Pinheiro, António Luiz Barbosa

doi:10.1016/j.jphotobiol.2019.111646

Cited by 10 publications

(2 citation statements)

References 21 publications

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“…For instance, DMMB exhibits higher potency in inhibiting monoamine oxidase A, compared to MethB (45). The photodynamic action of DMMB has been found to be more efficacious in treatment of microbial infections due to its high lipophilic character, compared to other photosensitizers, including MethB (46). An earlier study has demonstrated that MethB yielded a complex pattern of human BChE inhibition (Intrinsic K'=420±0.04 nM) and indicates cooperative binding at more than one site (47) whereas our results show that DMMB is a linear mixed-type inhibitior of human BChE (23±0.004 nM) and it is ~18-fold more potent than MethB.…”

Section: Discussionmentioning

confidence: 99%

Kinetics of human butyrylcholinesterase inhibition by 1,9-dimethyl-methylene blue

Biberoglu

2021

Journal of the Turkish Chemical Society Section A: Chemistry

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Alzheimer's disease (AD) is an irreversible and progressive neurodegenerative disorder, characterized by β-amyloid plaques, neurofibrillary tangles, and loss of cholinergic neurons. Butyrylcholinesterase (BChE) inhibition is a critical strategy for the treatment of AD since BChE causes inactivation of neurotransmitter acetylcholine and has positive effects on promoting the formation of βamyloid fibrils. Our previous studies showed that various phenothiazine-derived compounds such as thionine and toluidine blue O (TBO) cause a potent inhibition of human cholinesterases. TBO was also found to affect amyloid precursor protein processing in-vitro and in-vivo models of AD. In this study, it was aimed to determine the inhibitory effect of 1,9-dimethyl-methylene blue (DMMB), a phenothiazine-derived compound, on human plasma BChE and explore its inhibitory mechanism. The inhibition of human BChE was assessed by the colorimetric method of Ellman using butyrylthiocholine as substrate and 0-0.375 µM of DMMB. The kinetic findings showed that DMMB acts as a linear mixed-type inhibitor of human BChE with Ki value of 23 ± 0.004 nM and α= 3.6 ± 1.6. In conclusion, DMMB, which is a potent inhibitor effective at nM level, may be helpful in designing new cholinesterase inhibitors for the treatment of AD.

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Section: Discussionmentioning

confidence: 99%

Kinetics of human butyrylcholinesterase inhibition by 1,9-dimethyl-methylene blue

Biberoglu

2021

Journal of the Turkish Chemical Society Section A: Chemistry

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“…However, high doses are required for MB activity, leading to off target effects [17]. Following red light activation, MB is an efficient cytotoxic agent in vitro, acting through the increase of overall ROS production [4,18].…”

Section: Introductionmentioning

confidence: 99%

Metal‐Free Atom Transfer Radical Polymerization of PVDF‐Based Block Copolymers Catalyzed by Organic Photoredox Catalysts

Altomare¹,

Loos²

2023

Macro Chemistry & Physics

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Front Cover: In article 2200259 by Katja Loos and Aldo Altomare, the light‐catalyzed atom transfer radical polymerization (ATRP) of PVDF‐based block copolymers with methyl methacrylate using five different organic photoredox catalysts (OPRC) is reported. The authors prove how the three OPRC operating through an oxidative quenching pathway offer a good control over the process. They also achieve successful chain‐extension and external temporal control through light ON‐light OFF process. Cover design by Dina Maniar.

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Mitochondrial dysfunction mediates neuronal cell response to DMMB photodynamic therapy

Gomes

Marmolejo-Garza

Haan

et al. 2023

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

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A novel technique of antimicrobial photodynamic therapy – aPDT using 1,9-dimethyl-methylene blue zinc chloride double salt-DMMB and polarized light on Staphylococcus aureus

Cited by 10 publications

References 21 publications

Kinetics of human butyrylcholinesterase inhibition by 1,9-dimethyl-methylene blue

Kinetics of human butyrylcholinesterase inhibition by 1,9-dimethyl-methylene blue

Metal‐Free Atom Transfer Radical Polymerization of PVDF‐Based Block Copolymers Catalyzed by Organic Photoredox Catalysts

Mitochondrial dysfunction mediates neuronal cell response to DMMB photodynamic therapy

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