The shoulder joint and clavicle are innervated by the brachial plexus, the cervical plexus, and nerves to muscles around the joint and clavicle. Regional anesthesia is aimed at producing optimal surgical conditions, prolonging postoperative analgesia, being free of complications, reducing costs, and minimizing hospital stay. Regional upper extremity anesthesia can be achieved by blocking the brachial plexus at different stages along the course of the trunks, divisions, cords, and terminal branches. The gold standard of regional anesthesia for shoulder surgery is interscalene brachial plexus block plus cervical plexus block, but it is associated with a high rate of neurological complications and phrenic nerve block. The interest of the anesthesiologist has been directed towards regional blocks avoiding these complications; techniques that approach nerves more distally than interscalene block have been described. These approaches include supraclavicular nerves, upper trunk, suprascapular nerve by anterior approach, axillary nerve block in the axillary fossa, clavipectoral fascia block. The objective of this chapter is to describe the anatomy, sonoanatomy, technique, and the clinical utility of these accesses.