A novel therapeutic strategy for turban tumor: scalp excision and combined reconstruction with artificial dermis and split skin graft

Parren, Lizelotte J. M. T.; Ferdinandus, Patrick I.; Hulst, René van der; Frank, Jorge; Tuinder, Stefania

doi:10.1111/ijd.12199

Cited by 14 publications

(9 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to the very disfiguring nature of these head and neck, facial tumors, surgical removal and often repeated surgeries are performed on these individuals to limit tumor growth over their life-time. The psychological impacts due to the disfiguring appearance of affected individuals may lead to depression and social withdrawal [16].…”

Section: Introductionmentioning

confidence: 99%

The cylindromatosis (CYLD) gene and head and neck tumorigenesis

2016

View full text Add to dashboard Cite

Germline CYLD mutation is associated with the development of a rare inheritable syndrome, called the CYLD cutaneous syndrome. Patients with this syndrome are distinctly presented with multiple tumors in the head and neck region, which can grow in size and number over time. Some of these benign head and neck tumors can turn into malignancies in some individuals. CYLD has been identified to be the only tumor suppressor gene reported to be associated with this syndrome thus far. Here, we summarize all reported CYLD germline mutations associated with this syndrome, as well as the reported paired somatic CYLD mutations of the developed tumors. Interestingly, whole-exome sequencing (WES) studies of multiple cancer types also revealed CYLD mutations in many human malignancies, including head and neck cancers and several epithelial cancers. Currently, the role of CYLD mutations in head and neck carcinogenesis and other cancers is poorly defined. We hope that this timely review of recent findings on CYLD genetics and animal models for oncogenesis can provide important insights into the mechanism of head and neck tumorigenesis.

show abstract

Section: Introductionmentioning

confidence: 99%

The cylindromatosis (CYLD) gene and head and neck tumorigenesis

2016

View full text Add to dashboard Cite

show abstract

“…We performed the first review of the literature about studies that describe dermal substitutes’ utilisation in reconstruction after skin tumour excision. Table enlists publications available until July 2017 …”

Section: Discussionmentioning

confidence: 99%

“…Of them, 25 did not report data about recurrence or did not provide the complete text in English in order to evaluate this aspect . Eleven studies showed no recurrences among their patients, while 6 articles reported cases of recurrence that ranged from 5% to 25% …”

Section: Discussionmentioning

confidence: 99%

Skin cancers and dermal substitutes: Is it safe? Review of the literature and presentation of a 2‐stage surgical protocol for the treatment of non‐melanoma skin cancers of the head in fragile patients

Marcasciano

Mazzocchi

Kaciulyte

et al. 2018

International Wound Journal

View full text Add to dashboard Cite

Non-melanoma skin cancers (NMSC) represent the most common skin tumours of the head region. We describe the use of dermal substitute in a 2-stage surgery protocol for selected fragile patients to remove NMSC of the head region. A review of the literature focusing on dermal substitutes' safety after skin tumours excision is provided. A total of 45 fragile patients with NMSC in the head region were selected and scheduled for the 2-stage surgical protocol. The first stage consisted of traditional surgical excision and immediate coverage with Hyalomatrix (Fidia Advanced Biopolymers, Abano Terme, Italy). After histology confirmed diagnosis and clearance of the margins, full-thickness skin autografts were performed. All of the patients reached complete tumour excision and wound healing. No local recurrences were registered during 24 months follow up. The 2-stage surgical therapeutic-diagnostic-reconstructive approach represents a less stressful and oncologically safe surgical protocol in selected fragile patients. When patients cannot tolerate invasive and long surgical procedures, general anaesthesia, and long hospitalisation, skin grafting following temporary skin substitute coverage can achieve oncological clearance and provide good functional and aesthetic results. The use of dermal substitutes represents a valid alternative surgical option in cases of ASA III, fragile patients non-eligible for complex reconstructive surgery. To our knowledge, this is the first paper reviewing literature focusing on dermal substitutes' applications and safety after skin tumour excision.

show abstract

“…13 Total scalp excision followed by combined reconstruction with artificial dermis and split skin graft has been used in turban tumor cases, with good results. 10,14 Topical formulations containing salicylic acid or prostaglandin A1, which act by inhibiting NF-kB, are a possible nonablative treatment for solitary or small sized lesions. 4,14,15 …”

Section: 3810mentioning

confidence: 99%

“…10,14 Topical formulations containing salicylic acid or prostaglandin A1, which act by inhibiting NF-kB, are a possible nonablative treatment for solitary or small sized lesions. 4,14,15 …”

Section: 3810mentioning

confidence: 99%

Brooke-Spiegler Sydrome – an underrecognized cause of multiple familial scalp tumors: report of a new germline mutation

Pinho

Gouveia

Gameiro

et al. 2015

J Dermatol Case Rep

View full text Add to dashboard Cite

Background: Brooke-Spiegler syndrome (BSS) is probably an underdiagnosed genodermatosis that predisposes for the development of cylindromas, spiradenomas and trichoepitheliomas mainly of the head and neck. Wide phenotypic variability regarding the number and type of lesions can be observed within a family. Mutations of the CYLD gene are identified in the vast majority of cases and play a key role in BSS pathogenesis.Main observations: Two first degree relatives with numerous erythematous telangiectatic nodules of the scalp present for decades, with recurring tendency regardless the multiple previous excisions. Histopathological review of the lesions revealed predominantly "spiradenocylindromas" in the proband and cylindromas in her sister. The suspicion of BSS was confirmed after detection of a new nonsense germline mutation of CYLD (c.1783C>T pGln 595*) in the proband.Conclusions: BSS diagnosis can be challenging and is based on clinical-pathological correlation, positive familial association and identification of CYLD mutations. CYLD exerts antineoplastic effects by downregulating intracellular NF-κB signalling pathways. The reported mutation affecting the ubiquitin-specific protease domain leads to a truncated and catalytically inactive enzyme. Despite the expanding list of CYLD mutations no firm genotype-phenotype correlation is known so far. Early recognition and treatment of BSS avoid disfiguring changes like "turban tumor". (J Dermatol Case Rep. 2015; 9(3): 67-70)

show abstract

A novel therapeutic strategy for turban tumor: scalp excision and combined reconstruction with artificial dermis and split skin graft

Abstract: Treatment of turban tumor is a challenge considering the localization and extensiveness of the tumor masses. This novel therapy for turban tumor leads to a very good cosmetic and functional outcome.

Cited by 14 publications

References 14 publications

The cylindromatosis (CYLD) gene and head and neck tumorigenesis

The cylindromatosis (CYLD) gene and head and neck tumorigenesis

Skin cancers and dermal substitutes: Is it safe? Review of the literature and presentation of a 2‐stage surgical protocol for the treatment of non‐melanoma skin cancers of the head in fragile patients

Brooke-Spiegler Sydrome – an underrecognized cause of multiple familial scalp tumors: report of a new germline mutation

Contact Info

Product

Resources

About