A novel thixotropic magnesium phosphate-based bioink with excellent printability for application in 3D printing

Abstract

A novel magnesium phosphate-based gel (TMP-BG) with excellent printability was developed for application in 3D printing.

Hydrogels for Bioprinting: A Systematic Review of Hydrogels Synthesis, Bioprinting Parameters, and Bioprinted Structures Behavior

“…Finally, the last three papers use polycaprolactone (PCL) (Lin et al, 2016 ), a blend of polyurethane (PU), PCL, poly(L-lactic acid) (PLLA) and poly[D,L-lactic acid] (PDLLA) (Hsiao and Hsu, 2018 ), and Thixotropic Magnesium Phosphate-based gel (TMP-BG) (Chen et al, 2018 ). This last hydrogel is prepared mildly (gelling method) with inorganic compound and thixotropic features that obtains promising results.…”

“…From those 16 papers, six of them perform cross-linking at 37°C (Ren et al, 2016 ; McBeth et al, 2017 ; Law et al, 2018 ; Tijore et al, 2018a , b ; Zheng et al, 2018 ) and three use room temperature (Köpf et al, 2016 ; Lin et al, 2016 ; Berg et al, 2018 ). The rest use thermal cross-linking without specifying temperature (Fan et al, 2016 ; Giuseppe et al, 2017 ; Bandyopadhyay et al, 2018 ; Chen et al, 2018 ; Cochis et al, 2018 ; Xu X. et al, 2018 ). On the other hand, in alginate/gelatin hydrogels Berg et al ( 2018 ) uses room temperature, He et al ( 2016 ) uses a cool substrate, and Bandyopadhyay et al ( 2018 ) and Giuseppe et al ( 2017 ) use thermal cross-linking but without specific temperature.…”

“…Finally, other cells are used to a lesser extent: MG-63 (5) (Blaeser et al, 2013 ; Duarte Campos et al, 2013 ; Kim et al, 2016 ; McBeth et al, 2017 ; Chen et al, 2018 ), MC3T3 (4) (Peak et al, 2018 ; Wu D. et al, 2018 ; Yu et al, 2018 ; Noh et al, 2019 ), NHDF (3) (Ding et al, 2017 , 2018 ; Choi et al, 2018 ), 3T3 (3) (Wu Y. et al, 2018 ; Xu X. et al, 2018 ; Zheng et al, 2018 ), ATDC5 (3) (Izadifar et al, 2016 ; Hafeez et al, 2018 ; Kim et al, 2019 ), NSCs (2) (Lin et al, 2016 ; Kiyotake et al, 2019 ), Human Fibroblast (2) (Béduer et al, 2018 ; Zhang J. et al, 2018 ), PC12 (2) (Chen et al, 2019 ; Haring et al, 2019 ), HepG2 (2) (Bertassoni et al, 2014 ; Billiet et al, 2014 ), and iPSCs (2) (Nguyen et al, 2017 ; Maiullari et al, 2018 ).…”

Recent Developments of Biomaterials for Additive Manufacturing of Bone Scaffolds

“…[163] Another method for fabricating the MgP scaffold was based on the EB system, which stacks MgP slurry layer by layer into a 3D structure. [164,165] This method is simple and usually molded by utilizing the self-curing capability of MgP, so the printed structure has better biocompatibility and osteogenic activity. Ju-Ang Kim et al fabricated MgP scaffolds with different pore sizes and found that the scaffolds were completely degraded after 4 weeks of implantation in rabbit skull defect sites with simultaneous bone regeneration.…”

“…[ 163 ] Another method for fabricating the MgP scaffold was based on the EB system, which stacks MgP slurry layer by layer into a 3D structure. [ 164,165 ] This method is simple and usually molded by utilizing the self‐curing capability of MgP, so the printed structure has better biocompatibility and osteogenic activity. Ju‐Ang Kim et al.…”