A novel TMTC2-NTRK3 fusion in undifferentiated high-grade pleomorphic sarcoma

Bai, Chujie; Zhang, Lu; Wang, Yaohui; You, Xia; Ju, Yongzhi; Sun, Tingting; Fan, Zhengfu

doi:10.1007/s00432-022-04249-x

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…Firstly, with breakpoints analysis, numerous translocations were detected in the derivate or maker chromosomes as follow: t (1; 2), t (1; 3), t (1; 7), t (1; 10), t (1; 17), t (2; 3), t (5; 10), t (5; 11), t (5; 17), t (6; 8), t (6; 10), t (7; 10), t (9; 10), t (10; 11), t (10; 12), t (11; 17), and t (15; 21) ( Mairal et al, 2000 ). And the fusion genes with potential involvement in sarcomagenesis, like TMTC-NTRK3, LMNA-NTRK1, were identified ( Ali et al, 2019 ; Bai et al, 2022 ). Therefore, the chromosomal rearrangement was at play in the formation of composite karyotype.…”

Section: Who Opens Pandora's Box Of Ups/mfs?mentioning

confidence: 99%

Current research and management of undifferentiated pleomorphic sarcoma/myofibrosarcoma

Sun¹,

Liu²,

Hu³

et al. 2023

Front. Genet.

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Undifferentiated pleomorphic sarcoma (UPS), once termed as malignant fibrous histiocytoma, has always been diagnosed exclusively in clinical practice because it lacks any defined resemblance to normal mesenchymal tissue. Although myxofibrosarcoma (MFS) has been separated from UPS due to its fibroblastic differentiation with myxoid stroma, UPS and MFS are still identified as a sarcoma group in terms of molecular landscapes. In this review article, we will describe the associated genes and signaling pathways involved in the process of sarcoma genesis and make a summary of conventional management, targeted therapy, immunotherapy, and some novel potential treatments of UPS/MFS. With the progressive advancements in medical technology and a better understanding about the pathogenic mechanism of UPS/MFS in the coming decades, new lights will be shed on the successful management of UPS/MFS.

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Section: Who Opens Pandora's Box Of Ups/mfs?mentioning

confidence: 99%