A novel treatment for lupus nephritis: lignan precursor derived from flax

Clark, William F.; Muir, Alister D.; Westcott, Neil D.; Parbtani, Anwar

doi:10.1191/096120300678828622

Cited by 34 publications

(12 citation statements)

References 32 publications

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“…The other outcome that was clearly unrelated to gender was the reduction of proteinuria, considered a marker of glomerular injury, by FO. This benefit of n-3 PUFA enrichment has been described in both rodent and human studies, and may be a direct effect of the modification of prostanoid synthesis (15,16,49,50). The significance of this and other effects of histologic improvements in renal injury needs to be studied in longer-term, and therefore unfortunately more expensive, survival studies.…”

Section: Discussionmentioning

confidence: 90%

Effects of flaxseed derivatives in experimental polycystic kidney disease vary with animal gender

Ogborn

Nitschmann

Bankovic-Calic

et al. 2006

Lipids

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Flaxseed derivatives, including both oil and flax lignan, modify progression of renal injury in animal models, including Han:SPRD-cy polycystic kidney disease (PKD). Gender is a significant factor in the rates of progression of many forms of human renal disease, but the role of gender in the response to nutrition intervention in renal disease is unexplored. In this study, male and female Han:SPRD-cy rats or normal littermates were fed either corn oil (CO) or flax oil (FO) diets, with or without 20 mg/kg of the diet flax lignan secoisolaricinoresinol dyglycoside (SDG). Renal injury was assessed morphometrically and biochemically. Renal and hepatic PUFA composition was assessed by GC and renal PGE2 release by ELISA. FO preserved body weight in PKD males, with no effect in females. SDG reduced weight in both normal and PKD females. FO reduced proteinuria in both male and female PKD. FO reduced cystic change and renal inflammation in PKD males but reduced cystic change, fibrosis, renal inflammation, tissue lipid peroxides, and epithelial proliferation in PKD females. SDG reduced renal inflammation in all animals and lipid peroxides in PKD females. A strong interaction between SDG and FO was observed in renal FA composition of female kidneys only, suggesting increased conversion of C18 PUFA to C20 PUFA. FO reduced renal release of PGE2 in both genders. Gender influences the effects of flaxseed derivatives in Han:SPRD-cy rats. Gender-based responses to environmental factors, such as dietary lipid sources and micronutrients, may contribute to gender-based differences in disease progression rates.

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Section: Discussionmentioning

confidence: 90%

Effects of flaxseed derivatives in experimental polycystic kidney disease vary with animal gender

Ogborn

Nitschmann

Bankovic-Calic

et al. 2006

Lipids

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“…Flaxseed has recently undergone extensive study at Agriculture Canada and elsewhere [11][12][13][14][15] because it contains high amounts of ␣-linolenic acid [11,[15][16][17] and a potent phytoestrogen precursor, secoisolariciresinol diglucoside (SDG), which leads to production of mammalian lignans in humans (facultative organisms in the GI tract produce enterodiol and enterolactone, which are absorbed and achieve high plasma concentrations). The chief phytoestrogen, SDG, has been extracted by Agriculture Canada [18].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Flax Seed Cultivars with Differing Content of α-Linolenic Acid and Lignans on Responses to Mental Stress

Spence

Thornton

Muir

et al. 2003

Journal of the American College of Nutrition

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“…The beneficial effects of omega-3 fatty acids on human health are well established (Conners 2000;Simopoulos 2003). The ALA reduces the risk of cardiovascular disease (CVD), osteoporosis, rheumatoid arthritis and cancer (Prasad et al 1998;Clark et al 2000;Spence et al 2003;Aldercreutz 2007). There is, thus, an increasing interest in enriching the omega-3 fatty acid content of meat.…”

Section: Introductionmentioning

confidence: 99%

Growth performance and quality characteristics of flaxseed-fed broiler chicks

Mridula

Kaur

Nagra

et al. 2014

Journal of Applied Animal Research

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A 42-day study was conducted to evaluate the effect of ground full-fat flaxseed supplementation on growth performance, carcass characteristics, α-linolenic acid (ALA), linoleic acid (LA) and organoleptic characteristics of broiler meat. A total of 200 one-day-old broiler chicks were randomly allocated to five experimental groups and were fed isoenergetic and isonitrogenous diets containing flaxseed at 0%, 2.5%, 5.0%, 7.5% and 10%. Flaxseed supplementation did not affect the weekly body weight of broiler chicks during the first three weeks, but thereafter it reduced significantly with increasing levels of flaxseed in the diets. Birds fed on 10% flaxseed showed a reduction of 10.08% in body weight as compared to the control group. Diets containing 5.0-7.5% flaxseed resulted in significantly lower weight gain, higher feed conversion ratio, energy efficiency ratio and lower protein efficiency ratio as compared to control and 2.5% flaxseed diets. The carcass characteristics data indicated a little variation in the evisceration rate and giblet among treatment groups, but the breast yield was significantly higher in control than flaxseed groups. The protein, fat and ash content of broiler meat were not affected with the level of flaxseed in the diets. However, the inclusion of flaxseed in the diets significantly increased the ALA in the breast and thigh tissues with no difference in the organoleptic quality of meat.

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A novel treatment for lupus nephritis: lignan precursor derived from flax

Cited by 34 publications

References 32 publications

Effects of flaxseed derivatives in experimental polycystic kidney disease vary with animal gender

Effects of flaxseed derivatives in experimental polycystic kidney disease vary with animal gender

The Effect of Flax Seed Cultivars with Differing Content of α-Linolenic Acid and Lignans on Responses to Mental Stress

Growth performance and quality characteristics of flaxseed-fed broiler chicks

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