A Novel Treatment Strategy for Advanced Lacrimal Sac Carcinomas Confirmed by p16 Immunostaining

Ogawa, Toshihide; Yo, Kinga; Okamoto, Hiroki; Inukai, Daisuke; Yamanaka, Syunpei; Sano, Rui; Fujimoto, Yasushi; Ito, Makoto; Oshima, Yukihiko; Tsuzuki, Toyonori; Ueda, Ryuzo; Takahashi, Yasuhiro; Kakizaki, Hirohiko

doi:10.1080/08820538.2021.1963458

Cited by 9 publications

(15 citation statements)

References 21 publications

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“…Orbital exenteration and resection of the paranasal sinus may be needed for extensive primary or secondary malignant lesions 6,8,12,19 . The balance of surgical radicality and preserving quality of life is similar to trade off thinking for these cases 14 . In the present case, the neoplastic lesion was invaded the medial rectus orbital muscle, ethmoid, nasal cavity, medial concha and maxillary sinus.…”

Section: Discussionmentioning

confidence: 55%

“…There is also no high‐quality evidence on the use of chemotherapy in advanced lacrimal sac carcinoma to date. In sum, there is a lack of consensus and evidence on standard treatment strategies for advanced lacrimal sac carcinoma 14 . Adjuvant treatment modalities include external beam RT, local RT (plaque brachytherapy), proton therapy, chemotherapy (CHOP regimen) or immunotherapy 6,20 .…”

Section: Discussionmentioning

confidence: 99%

“…Primary epithelial malignancies of the lacrimal apparatus, comprising the lacrimal gland, duct, and sac, are extraordinarily and uncommon rare tumors with significant recurrence rates. [1][2][3][4][11][12][13][14] As noted by Singh and Ali 5 among primary malignant epithelial tumors, squamous cell carcinomas were the most common (61%), followed by transitional cell carcinomas (15%), and mucoepidermoid carcinoma (7%). Because of their rarity, no extensive clinical data on their management and prognosis exist.…”

Section: Discussionmentioning

confidence: 99%

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Lacrimal sac squamous cell carcinoma: From resection to prosthetic rehabilitation. A case report

Poghosyan,

Gharakeshishyan,

Misakyan

et al. 2023

Clinical Case Reports

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Key Clinical MessageThere is a lack of consensus and evidence on treatment strategies for lacrimal sac carcinomas. Wide en bloc surgical resection with farther prosthetic rehabilitation could be the treatment option in certain cases.AbstractMalignant epithelial lacrimal sac tumors are rare cancers with high recurrence rates. Diagnosis of these tumors is often delayed as they are confused with chronic dacryocystitis. There is a lack of consensus and evidence on standard treatment strategies for advanced lacrimal sac carcinomas. A case of advanced lacrimal sac squamous cell carcinoma treated with wide en bloc margin‐negative surgical resection with further prosthetic rehabilitation without adjuvant therapy and 38 months of recurrence‐free postoperative follow‐up is presented.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Lacrimal sac squamous cell carcinoma: From resection to prosthetic rehabilitation. A case report

Poghosyan,

Gharakeshishyan,

Misakyan

et al. 2023

Clinical Case Reports

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show abstract

“…6,8,12,19 The balance of surgical radicality and preserving quality of life is similar to trade off thinking for these cases. 14 In the presented case the neoplastic lesion was invaded the medial rectus orbital muscle, ethmoid, nasal cavity, medial concha and maxillary sinus. Wide en blocsurgical removal could be more life-lengthening for this case than organ-preserving operation tactics and radiation therapy.…”

Section: Discussionmentioning

confidence: 68%

“…Primary epithelial malignancies of the lacrimal apparatus, comprising the lacrimal gland, duct, and sac, are extraordinarily and uncommon rare tumors with significant recurrence rates. [1][2][3][4][11][12][13][14] As noted by Singh and Ali (2021) 5 among primary malignant epithelial tumors, squamous cell carcinomas were the most common (61%), followed by transitional cell carcinomas (15%) and mucoepidermoid carcinoma (7%). Because of their rarity, no extensive clinical data on their management and prognosis exist.…”

Section: Discussionmentioning

confidence: 85%

Lacrimal Sac Squamous Cell Carcinoma: From Resection to Prosthetic Rehabilitation. A Case Report

Mashinyan

Kharazyan

2023

Preprint

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Malignant epithelial lacrimal sac tumors are rare cancers with high recurrence rates. Diagnosis of these tumors is often delayed as they are confused with chronic dacryocystitis. There is a lack of consensus and evidence on standard treatment strategies for advanced lacrimal sac carcinomas. A case of advanced lacrimal sac squamous cell carcinoma treated with wide en bloc margin-negative surgical resection with further prosthetic rehabilitation without adjuvant therapy and 38 months of recurrence-free postoperative follow-up is presented.

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Effectiveness of Nasolacrimal SCC Treatments and Promising Role of Chemo‐Induction: A Case Report and Systematic Review

Alsavaf,

Abouammo,

Bhuskute

et al. 2024

The Laryngoscope

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ObjectiveTo comprehensively analyze reported cases of nasolacrimal squamous cell carcinoma (NLSCC), focusing on risk factors, treatment modalities, and outcomes. Additionally, investigate the impact of human Papillomavirus (HPV) status and histopathological subtypes' impact on prognosis.Data SourcesPubmed, Embase.Review MethodsWe conducted a systematic literature review to identify relevant studies reporting cases of NLSCC. The review methods adhered to Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines. The final update was performed on May 31, 2023.ResultsThe 72 studies included a total of 313 participants (mean age: 55; 60% male). Longer symptom duration (44.1 ± 59.2 months) correlated with recurrence (p = 0.004), and males exhibited higher mortality rates (19.6% vs. 2.4% in females, p = 0.01). The overall survival (OS) rate among all patients was 87.1%. Basaloid NLSCC had a worse death outcome (p ≤ 0.001). HPV‐positive cases showed comparable OS, recurrence, and metastasis rates to the general population (p = 0.917, 0.851, 0.07, respectively). Comparing treatment approaches (surgery, surgery with adjuvant radiation, chemoradiotherapy [CRT] followed by surgery), no significant differences in 5 and 10‐year OS rates or recurrence were observed (p = 0.4, 0.24, respectively), but 5‐year metastasis events were significant (p = 0.024). Eye exenteration rates were 31.1%, 20%, and 0% for the respective treatments (p = 0.089). Induction chemotherapy saved four cases from potential exenteration with favorable prognosis.ConclusionEarly detection and diagnosis are of utmost importance in the management of NLSCC. Regardless of the treatment approach, HPV‐related NLSCC demonstrated similar outcomes to the general population. Basaloid histology represents the worst subtype in terms of prognosis. Limited adjuvant CRT cases showed improved outcomes and induction chemotherapy's importance was emphasized in recent literature and our shared experience. Laryngoscope, 2024

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A Novel Treatment Strategy for Advanced Lacrimal Sac Carcinomas Confirmed by p16 Immunostaining

Cited by 9 publications

References 21 publications

Lacrimal sac squamous cell carcinoma: From resection to prosthetic rehabilitation. A case report

Lacrimal sac squamous cell carcinoma: From resection to prosthetic rehabilitation. A case report

Lacrimal Sac Squamous Cell Carcinoma: From Resection to Prosthetic Rehabilitation. A Case Report

Effectiveness of Nasolacrimal SCC Treatments and Promising Role of Chemo‐Induction: A Case Report and Systematic Review

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