A novel trigeminal neuropathic pain model: Compression of the trigeminal nerve root produces prolonged nociception in rats

Jeon, Hye Jin; Han, Seung Ro; Park, Min K; Yang, Kun; Bae, Yong Chul; Ahn, Dong Kuk

doi:10.1016/j.pnpbp.2012.03.002

Cited by 39 publications

(33 citation statements)

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“…In volunteers with different blood pressures, the critical extraneural pressure threshold above which function was blocked was 3.99 kPa (30 mmHg) less than the diastolic pressure and 5.98 kPa (45 mmHg) below mean arterial blood pressure. The correlation between systemic blood pressure and neurological function in response to acute compression supports the hypothesis that decreased microvascular blood flow plays an important role in nerve compression[5556]. …”

Section: Discussionsupporting

confidence: 57%

Optimal duration of percutaneous microballoon compression for treatment of trigeminal nerve injury

Han

et al. 2014

Neural Regen Res

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Percutaneous microballoon compression of the trigeminal ganglion is a brand new operative technique for the treatment of trigeminal neuralgia. However, it is unclear how the procedure mediates pain relief, and there are no standardized criteria, such as compression pressure, compression time or balloon shape, for the procedure. In this study, percutaneous microballoon compression was performed on the rabbit trigeminal ganglion at a mean inflation pressure of 1,005 ± 150 mmHg for 2 or 5 minutes. At 1, 7 and 14 days after percutaneous microballoon compression, the large-diameter myelinated nerves displayed axonal swelling, rupture and demyelination under the electron microscope. Fragmentation of myelin and formation of digestion chambers were more evident after 5 minutes of compression. Image analyzer results showed that the diameter of trigeminal ganglion cells remained unaltered after compression. These experimental findings indicate that a 2-minute period of compression can suppress pain transduction. Immunohistochemical staining revealed that vascular endothelial growth factor expression in the ganglion cells and axons was significantly increased 7 days after trigeminal ganglion compression, however, the changes were similar after 2-minute compression and 5-minute compression. The upregulated expression of vascular endothelial growth factor in the ganglion cells after percutaneous microballoon compression can promote the repair of the injured nerve. These findings suggest that long-term compression is ideal for patients with recurrent trigeminal neuralgia.

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Section: Discussionsupporting

confidence: 57%

Optimal duration of percutaneous microballoon compression for treatment of trigeminal nerve injury

Han

et al. 2014

Neural Regen Res

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“…To test pain-related behavior in animals, most studies manipulate the plantar surface of the hindpaw, where there is no fur 1 , 3 , 5 , 19 , 20 , 27 , 28) . In the present study, although the surgical site in the suboccipital and posterior neck region was thoroughly shaved after anesthesia, minute amount of fur grew several days after shaving, which may hinder the precise testing of cold allodynia.…”

Section: Discussionmentioning

confidence: 99%

Cold Allodynia after C2 Root Resection in Sprague-Dawley Rats

Chung¹,

Cho

Park

et al. 2018

J Korean Neurosurg Soc

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ObjectiveThe purpose of this study was to evaluate pain-related behaviors after bilateral C2 root resection and change in pain patterns in the suboccipital region in rats.MethodsMale Sprague-Dawley rats were randomly assigned to three groups (n=25/group); näive, sham, and C2 resection. Three, 7, 10, and 14 days after surgery, cold allodynia was assessed using 20 μL of 99.7% acetone. c-Fos and c-Jun were immunohistochemically stained to evaluate activation of dorsal horn gray matter in C2 segments of the spinal cord 2 hours, 1 day, 7 days, and 14 days after surgery.ResultsThree days after surgery, the response to acetone in the sham group was significantly greater than in the näive group, and this significant difference between the näive and sham groups was maintained throughout the experimental period (p<0.05 at 3, 7, 10, and 14 days). Seven, 10, and 14 days after surgery, the C2 root resection group exhibited a significantly greater response to acetone than the näive group (p<0.05), and both the sham and C2 resection groups exhibited significantly greater responses to acetone compared with 3 days after surgery. No significant difference in cold allodynia was observed between the sham and C2 root resection groups throughout the experimental period. Two hours after surgery, both the sham and C2 root resection groups exhibited significant increases in c-Fos- and c-Jun-positive neurons compared with the naive group (p=0.0021 and p=0.0358 for the sham group, and p=0.0135 and p=0.014 for the C2 root resection group, respectively). One day after surgery, both the sham and C2 root resection groups exhibited significant decreases in c-Fos -positive neurons compared with two hours after surgery (p=0.0169 and p=0.0123, respectively), and these significant decreases in c-Fos immunoreactivity were maintained in both the sham and C2 root resection groups 7 and 14 days after surgery. The sham and C2 root resection groups presented a tendency toward a decrease in c-Jun-positive neurons 1, 7, and 14 days after surgery, but the decrease did not reach statistical significance.ConclusionWe found no significant difference in cold allodynia and the early expression of c-Fos and c-Jun between the sham and C2 resection groups. Our results may support the routine resection of the C2 nerve root for posterior C1–2 fusion, but, further studies are needed.

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“…To validate the efficacy of our proposed device, several orofacial pain models were considered, including nerve injury (Bennett and Xie, 1988; Jeon et al, 2012; Vos and Strassman, 1994) and neurogenic inflammation (Okumura et al, 2010; Pelissier et al, 2002; Poh et al, 2009; Ro et al, 2009, 2007; Xu et al, 2010). Of these, capsaicin injections are particularly useful in modeling temporary heightened nociception, as sensitivity decreases within a few hours, allowing for subsequent baseline testing several days after experimental testing.…”

Section: Discussionmentioning

confidence: 99%

A novel operant-based behavioral assay of mechanical allodynia in the orofacial region of rats

Rohrs

Kloefkorn

Lakes

et al. 2015

Journal of Neuroscience Methods

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Background Detecting behaviors related to orofacial pain in rodent models often relies on subjective investigator grades or methods that place the animal in a stressful environment. In this study, an operant-based behavioral assay is presented for the assessment of orofacial tactile sensitivity in the rat. New Methods In the testing chamber, rats are provided access to a sweetened condensed milk bottle; however, a 360° array of stainless steel wire loops impedes access. To receive the reward, an animal must engage the wires across the orofacial region. Contact with the bottle triggers a motor, requiring the animal to accept increasing pressure on the face during the test. To evaluate this approach, tolerated bottle distance was measured for 10 hairless Sprague-Dawley rats at baseline and 30 minutes after application of capsaicin cream (0.1%) to the face. The experiment was repeated to evaluate the ability of morphine to reverse this effect. Results The application of capsaicin cream reduced tolerated bottle distance measures relative to baseline (p<0.05). As long as morphine did not cause reduced participation due to sedation, subcutaneous morphine dosing reduced the effects of capsaicin (p<0.001). Comparison with Existing Method For behavioral tests, experimenters often make subjective decisions of an animal’s response. Operant methods can reduce these effects by measuring an animal’s selection in a reward-conflict decision. Herein, a method to measure orofacial sensitivity is presented using an operant system. Conclusions This operant device allows for consistent measurement of heightened tactile sensitivity in the orofacial regions of the rat.

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A novel trigeminal neuropathic pain model: Compression of the trigeminal nerve root produces prolonged nociception in rats

Cited by 39 publications

References 50 publications

Optimal duration of percutaneous microballoon compression for treatment of trigeminal nerve injury

Optimal duration of percutaneous microballoon compression for treatment of trigeminal nerve injury

Cold Allodynia after C2 Root Resection in Sprague-Dawley Rats

A novel operant-based behavioral assay of mechanical allodynia in the orofacial region of rats

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