A novel triple templates molecularly imprinted biosensor assisted by second-order calibration methods based on generation of second-order hydrodynamic linear sweep voltammetric data for simultaneous biosensing of insulin, proinsulin and C-peptide: Application to comparing PARAFAC2 and PARASIAS

Jalalvand, Alí R.; Pinto, Licarion

doi:10.1016/j.chemolab.2022.104746

Cited by 8 publications

(2 citation statements)

References 31 publications

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“…The findings regarding the pH and temperature effects are in line with the established understanding that biosensor responses are highly sensitive to environmental conditions (22,23). The optimal conditions identified for pH and temperature are crucial for maintaining the functional activity and structural integrity of the insulin tracer protein, thereby ensuring accurate biosensor readings.…”

Section: Impact Of Physicochemical Conditionssupporting

confidence: 73%

Design of an Insulin Tracer Protein-Based Biosensor for Insulin Determination

Yaşar,

Kökbaş,

Yaşar

2024

Medical Records

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The regulation of blood glucose levels is controlled by insulin, which is produced by the pancreatic beta system. Inadequate synthesis of beta insulin, results in elevated glucose levels, a condition known as diabetes, which can lead to various chronic health issues. In recent times, the diagnosis of diabetes, particularly type 1, has shifted towards the direct measurement of insulin levels. To facilitate this, an immunosensor was created to enable rapid and sensitive examination of insulin levels, with the goal of improving the quality for life for diabetic patients. For this purpose, an insulin tracer protein based biosensor was designed for the determination of insulin at all solutions. For determination of insulin, electrobiochemical analyses were performed. The insulin biosensor cyclic woltammogram was obtained between -0,1 and 0,6 V potantial. At 0,45 V was found as the anodic peak side for determination the insulin. Optimisation and characterisation studies performed at 0,45 V with differential pulse voltammetry. The study successfully identified stable and easy-to-use insulin concentrations, indicating the potential of the newly developed immunosensor for applications in clinical biochemistry laboratories.

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Section: Impact Of Physicochemical Conditionssupporting

confidence: 73%

Design of an Insulin Tracer Protein-Based Biosensor for Insulin Determination

Yaşar,

Kökbaş,

Yaşar

2024

Medical Records

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“…The sensor presented linear detection ranged from 1.0 × 10 −7 to 1.0 × 10 −6 mol L −1 with the detection limit of 10.2 nM. The simultaneous detection of three chemical species - insulin, proinsulin and C-peptides, was achieved by mixing those species with N-methacryloyl-(L) 3-histidine methyl ester, 2-hydroxyethyl methacrylate and ethylene glycol dimethacrylate, followed by the polymerization of the precursors under UV at the surface of the electrode (thick-film boron doped diamond electrode) [ 261 ]. The detection limit was in the range of 1–16 pM for insulin, 4–25 pM for proinsulin and 8–88 pM for C-peptide, respectively, in both artificial and real human serum samples.…”

Section: Biomedical Applications Of Membranesmentioning

confidence: 99%

Polymeric Membranes for Biomedical Applications

2023

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Polymeric membranes are selective materials used in a wide range of applications that require separation processes, from water filtration and purification to industrial separations. Because of these materials’ remarkable properties, namely, selectivity, membranes are also used in a wide range of biomedical applications that require separations. Considering the fact that most organs (apart from the heart and brain) have separation processes associated with the physiological function (kidneys, lungs, intestines, stomach, etc.), technological solutions have been developed to replace the function of these organs with the help of polymer membranes. This review presents the main biomedical applications of polymer membranes, such as hemodialysis (for chronic kidney disease), membrane-based artificial oxygenators (for artificial lung), artificial liver, artificial pancreas, and membranes for osseointegration and drug delivery systems based on membranes.

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