A novel triruthenium nitrosyl bearing a quinolinic ligand: a comparison of its spectroscopic behavior with its pyridine analogues

Abstract

A comparative analysis of ruthenium nitrosyl spectroscopic data helps unravel the electronic character of the unit {RuNO}6[RuIIIRuIIIO].

Water‐Soluble μ‐oxo triruthenium Compound of Biological Interest: H‐Bonds Network and Interaction with HSA

“…[7] Interest in their biological applications is relatively recent, and our research group has been at the forefront of this field, publishing studies revealing their in vitro anticancer, trypanocidal, and vasodilator properties. [8][9][10][11][12][13][14] Different approaches were used to achieve these properties, including coordinating functional biomolecules like NO and CO that can be released through photoactivation; [11,13,[15][16][17] coordination of quinolinic ligands; [12,18] and exploring the ortho-metalation of phenazines to introduce a metalo-intercalator within the triruthenium cluster structure. [8] Careful selection of ancillary ligands was crucial to achieve those specific properties.…”

Interactions with HSA, anticancer and antiallergic activity of binuclear μ‐oxo bridged ruthenium acetate compounds

“…(2) directly act as vasodilating, anticancer, and trypanocidal agents; and (3) interact with biomolecules such as HSA and DNA. [26][27][28][29][30][31][32][33][34][35] Regarding biological applications, the chemistry of binuclear μ-oxo ruthenium analogs has naturally caught our attention because, in this class of compounds, the reactivity at the trans-position to the μ-oxo bridge may promote the delivery of specific chemical species or lead the complexes to bind to biological targets. Besides that, the exchange of acetate bridges for other carboxylates introduces new possibilities.…”

“…We have successfully contributed to the investigation of metallodrug candidates based on the trinuclear motif [Ru 3 O(CH 3 COO) 6 (L) 3 ] n . Depending on the ancillary ligands, such compounds may (1) act as pro‐drugs that deliver relevant active molecules such as NO and CO; (2) directly act as vasodilating, anticancer, and trypanocidal agents; and (3) interact with biomolecules such as HSA and DNA [26–35] . Regarding biological applications, the chemistry of binuclear μ‐oxo ruthenium analogs has naturally caught our attention because, in this class of compounds, the reactivity at the trans ‐position to the μ‐oxo bridge may promote the delivery of specific chemical species or lead the complexes to bind to biological targets.…”

Reatividade de acetatos trinucleares de rutênio com ligantes nitrito e óxido nítrico em meio aquoso

“…Além disso, gases terapêuticos são caracterizados por possuírem tempo de meia-vida extremamente curto, além de serem difíceis de acumular efetivamente em tecidos-alvo, levando a uma eficácia limitada da terapia com gás, gerando efeitos terapêuticos não desejados e podendo até causar efeitos antagônicos (HEINRICH et al, 2013;SARKAR;KUMAR;MATSON, 2023). Para resolver esses problemas, os pesquisadores desenvolvem atualmente diversos doadores de NO e pró-drogas, à exemplo do nosso grupo de pesquisa (CACITA et al, 2015;DA SILVA et al, 2018;SANTOS et al, 2022). (MCCLEVERTY, 2004;NICHOLS et al, 2012;WANG et al, 2002).…”

“…Os nitrosilos trinucleares de rutênio consistem em uma classe de compostos com fórmula [Ru3O(CH3COO)6)(L)2(NO)] + onde L = ligantes N-heterocíclicos. Sobre essa classe de compostos, quando comparadas à outros nitrosilos complexos de rutênio, a literatura nos aponta um número menor de trabalhos a respeito tanto de síntese e caracterização desses compostos, quanto das propriedades químicas ou reatividades dos mesmos (CACITA et al, 2015;CARNEIRO et al, 2014;DA SILVA et al, 2018;DE LIMA et al, 2023;HIGASHIJIMA, 2018;FUJIWARA;YAMAGUCHI, 2011;SANTOS et al, 2022;TOMA et al, 2005;DOVIDAUSKAS, 2002).…”