A Novel Triterpene from the Roots of Paullinia pinnata: 6α-(3′-methoxy-4′-hydroxybenzoyl)-lup-20(29)-ene-3-one

Abstract

Paullinia pinnata L. (Sapindaceae) is an endemic West African plant that is extensively used in traditional medicine to treat various diseases. Previous phytochemical analysis by various groups led to the isolation of several novel lupene-based triterpenene derivatives along with other classes of compounds. As part of our continued phytochemical studies on the roots of this plant, we have now identified yet another novel triterpene, 6-(3'-methoxy-4'hydroxybenzoyl)-lup-20(29)-ene-3-one. The identification of the compound through comprehensive spectroscopic studies is discussed.

A Hydroalcoholic Extract from Paullinia pinnata L. Roots Exerts Anthelmintic Activity against Free-Living and Parasitic Nematodes

“…Except for one study showing vasorelaxant effects of a methanolic extract from the leaves and roots of P. pinnata and dealing with the presence of tannins and flavonoids as the major compounds [16], the majority of published data on P. pinnata focus on the more lipophilic constituents. Most of the compounds previously isolated from the roots belong to the group of lupane-type triterpenoids [17][18][19] and were shown to possess fibroblast stimulatory [17] as well as moderate antibacterial activities [19]. Further, friedelin, β-sitosterol, and β-sitosterolglucoside have been isolated from the leaves [20] and roots [21], and the composition of fatty acids has been determined [21].…”

The Ethanolic Leaf Extracts of Dissotis multiflora (Sm) Triana and Paullinia pinnata Linn Exert Inhibitory Effect on Escherichia coli Through Membrane Permeabilization, Loss of Intracellular Material, and DNA Fragmentation

“…Paullinia pinnata Linn (Sapindaceae) family is an important medicinal plant used in many indigenous medical systems for the treatment of infectious diseases 24 . Several studies revealed antibacterial and antidiarrheal activities of extracts and isolated compounds from P. pinnata [25][26][27][28][29][30] . D. multiflora and P. pinnata have shown promising antibacterial activities.…”

Anthelmintic A-Type Procyanidins and Further Characterization of the Phenolic Composition of a Root Extract from Paullinia pinnata

“…Regarding their phytochemical composition, extracts from leaves and roots of P. pinnata have been quite extensively investigated, however, the polarity of these extracts was mainly in the semi-polar to non-polar range. Thus, several lupane-type triterpenoids [13][14][15] with fibroblast stimulatory [13] and moderate antibacterial activities [15] have been isolated from the roots. Further, leaves and roots were found to contain the phytosterols friedelin, β-sitosterol and β-sitosterolglucoside [16,17] as well as a variety of fatty acids [16].…”