A novel tumor‐node‐metastasis (TNM) staging system of diffuse malignant peritoneal mesothelioma using outcome analysis of a multi‐institutional database*

Yan, Tristan D.; Deraco, Marcello; Élias, Dominique; Gléhen, Olivier; Levine, Edward A.; Moran, Brendan; Morris, David L.; Chua, Terence C.; Piso, Pompiliu; Sugarbaker, Paul H.

doi:10.1002/cncr.25640

Cited by 135 publications

(108 citation statements)

References 23 publications

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“…10,[13][14][15] Consequently, various staging systems have been proposed to identify appropriate surgical candidates, stratify treatment regimens and more accurately predict prognosis. 43,44 Although the Figure 3 Kaplan-Meier curves compare the cumulative probability for progression-free survival and overall survival among peritoneal mesotheliomas with homozygous CDKN2A deletions (a and b, respectively) and hemizygous NF2 loss (c and d, respectively). Patients with both homozygous CDKN2A deletion and hemizygous NF2 loss had a shorter progression-free survival (e), and worse overall survival (f) than patients with alterations in either gene alone.…”

Section: Discussionmentioning

confidence: 99%

The prognostic significance of BAP1, NF2, and CDKN2A in malignant peritoneal mesothelioma

et al. 2016

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Cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion for patients with malignant peritoneal mesothelioma has resulted in improved disease control and increased survival. Despite these results, there are significant perioperative risks associated with this aggressive procedure that necessitate consideration of prognostic markers during patient selection. The molecular pathogenesis of peritoneal mesothelioma remains relatively unknown, but extrapolation of findings from their pleural counterpart would suggest frequent alterations in CDKN2A, NF2, and BAP1. Homozygous deletions in CDKN2A portend a worse overall survival in peritoneal mesothelioma. However, the prevalence and prognostic significance of NF2 and BAP1 abnormalities has not been studied. Dual-color fluorescence in situ hybridization using CDKN2A and NF2 locus-specific probes and BAP1 immunohistochemistry identified homozygous CDKN2A deletions (n = 25, 29%), hemizygous NF2 loss (n = 30, 35%), and/or loss of BAP1 protein expression (n = 49, 57%) in 68 of 86 (79%) peritoneal mesotheliomas. Homozygous CDKN2A deletions or hemizygous NF2 loss correlated with shorter progressionfree survival (Po 0.02) and poor overall survival (Po 0.03). Moreover, the significance of these findings was cumulative. Patients harboring both homozygous CDKN2A deletions and hemizygous NF2 loss had a 2-year progression-free survival rate of 9% with a median of 6 months (Po 0.01) and overall survival rate of 18% with a median of 8 months (Po 0.01). By multivariate analysis, combined homozygous CDKN2A deletions and hemizygous NF2 loss was a negative prognostic factor for both progression-free survival and overall survival, independent of patient age, peritoneal cancer index, completeness of cytoreduction, and extent of invasion. In contrast, loss of BAP1 was not associated with clinical outcome. In summary, homozygous deletions in CDKN2A and hemizygous loss of NF2 as detected by fluorescence in situ hybridization would confer a poor clinical outcome and may guide future treatment decisions for patients with peritoneal mesothelioma.

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Section: Discussionmentioning

confidence: 99%

The prognostic significance of BAP1, NF2, and CDKN2A in malignant peritoneal mesothelioma

et al. 2016

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“…Another explanation can be that the patient presented a congenital mobile right colon, and the initial disease developed in the peritoneum in the right colic gutter. Moreover, in diffuse peritoneal mesothelioma there is the possibility of regional [13] or distant [14] lymph node metastasis, in our case the retroperitoneal tumour could have been an enlarged metastatic lymph node. This is unlikely, due to the dimension of the tumor and the description on histopathological examination.…”

Section: Discussionmentioning

confidence: 59%

Rare localization of malignant peritoneal mesothelioma

Huțanu¹,

Filip²,

Buna³

et al. 2015

Arch Clin Cases

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Peritoneal mesothelioma represents a rare disease, among its manifestations it can be encountered ascites and tumoral abdominal masses and this condition, untreated can lead to death by bowel obstruction, perforation and cachexia. Due to the rarity of the disease, some patients are misdiagnosed and thus they cannot benefit from a radical form of treatment which leads to an increased survival. We hereby present the case of a 62 year-old male with previous surgery for a retroperitoneal tumor with relapse of the disease. The pathological examination and immunochemistry showed a diffuse peritoneal mesothelioma with poor differentiation. The patient was submitted to chemotherapy and 16 months after surgery on regular control imaging he presented a retroperitoneal recurrence. Unfortunately the patient refused the treatment; we believe that he could benefit from radical surgery associated with hyperthermic intraperitoneal chemotherapy. Preoperative diagnosis of diffuse peritoneal mesothelioma can be difficult due to the lowest predictability of the clinical and imaging studies.

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“…Good prognostic indicators in our case included age less than 50, female gender localized disease and no lymph node metastases. [10] Our patient met all the criteria, and hence was treated with complete cytoreduction only. The 5-year survival with such treatment is around 90%.…”

Section: Discussionmentioning

confidence: 79%

Papillary mesothelioma of peritoneum involving fallopian tube: A challenging case

Quershi

Gowri

Burney

et al. 2016

JST

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A novel tumor‐node‐metastasis (TNM) staging system of diffuse malignant peritoneal mesothelioma using outcome analysis of a multi‐institutional database*

Cited by 135 publications

References 23 publications

The prognostic significance of BAP1, NF2, and CDKN2A in malignant peritoneal mesothelioma

The prognostic significance of BAP1, NF2, and CDKN2A in malignant peritoneal mesothelioma

Rare localization of malignant peritoneal mesothelioma

Papillary mesothelioma of peritoneum involving fallopian tube: A challenging case

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