A Novel Turn-On Fluorescence Probe Based on Cu(II) Functionalized Metal–Organic Frameworks for Visual Detection of Uric Acid

Abstract

As an important biomarker in urine, the level of uric acid is of importance for human health. In this work, a Cu(II) functionalized metal–organic framework (Cu2+@Tb-MOFs) is designed and developed as a novel fluorescence probe for wide-range uric acid detection in human urine. The study shows that this fluorescence platform demonstrated excellent pH-independent stability, high water tolerance, and good thermal stability. Based on the strong interaction between metal ions and uric acid, the designed Cu2+@Tb-MOFs can be employed as efficient turn-on fluorescent probes for the detection of uric acid with wide detection range (0~104 µM) and high sensitivity (LOD = 0.65 µM). This probe also demonstrates an anti-interference property, as other species coexisted, and the possibility for recycling. The sensing mechanisms are further discussed at length. More importantly, we experimentally constructed a molecular logic gate operation based on this fluorescence probe for intelligent detection of uric acid. These results suggest the Cu(II) functionalized metal–organic framework can act as a prominent candidate for personalized monitoring of the concentration of uric acid in the human urine system.

Luminescent Materials with Turn-on and Ratiometric Sensory Response Based on Coordination Compounds of Lanthanides

“…The effect is due to the lock-and-key matching of the channel diameters in the MOF sensor structure with the sizes of the indicated alcohol molecules. The QFR mechanism (Figure 3) has been often implemented using notluminescent copper-lanthanide heterometallic complexes capable of "donating" copper ions under the action of various analytes, especially those containing sulfur [9][10][11][12] and nitrogen [12][13][14] donor atoms with a high affinity for copper ions. This approach makes it possible to achieve greater selectivity with respect to background ions not strongly interacting with Cu 2+ ions.…”

A Novel Dye-Modified Metal-Organic Framework as Bifunctional Fluorescent Probe for Visual Sensing for Styrene and Temperature

“…The Tb-MOFs sample is synthesized by a fast and facile method at room temperature condition [27,28]. The C460@Tb-MOFs composites were synthesized by simple ultrasonic impregnation method.…”

PEI-Mediated Assembly of Fe3O4 onto SiO2-Encapsulated CsPbBr3 for Highly Sensitive Fluorescent Lateral Flow Immunoassay

“…Colloidal gold nanoparticles (Au NPs) have traditionally been employed for colorimetric detection, offering stable results and rapid readouts through the localized surface plasmon resonance (LSPR) effect. However, Au NPs suffer from limited sensitivity and weak quantitative capabilities. , In recent years, fluorescent materials such as quantum dots (QDs), , organic fluorescent probes, luminescent lanthanum-doped nanoparticles, metal–organic frameworks (MOFs), and silicon-based nanoparticles have been used in conjunction with LFIA, benefiting from their high sensitivity and low background interference. Unfortunately, these materials often involve complex synthesis, photobleaching, low quantum yield, or the need for intricate organic ligands.…”