A novel two-dimensional phantom for electrical impedance tomography using 3D printing

Creegan, Andrew; Nielsen, Poul M. F.; Tawhai, Merryn H.

doi:10.1038/s41598-024-52696-y

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…Phantoms or tissue-mimicking materials are used widely in biomedical research for both diagnostic and therapeutic applications [ 1 , 2 , 3 , 4 , 5 ] including computed X-ray tomography [ 6 ], elastography [ 7 ], single photon emission computed tomography [ 8 ], positron emission tomography [ 9 ], magnetic resonance imaging [ 10 ], ultrasound [ 11 ], electrical impedance tomography [ 12 ], photocurrent imaging [ 13 ], optical imaging and spectroscopy [ 14 ], image processing [ 15 ], radiotherapy [ 16 ], thermal therapy [ 17 ], and surgical applications [ 18 ]. Biomimetic properties are also important for artificial membranes employed with organ-on-a-chip systems [ 19 , 20 , 21 , 22 ] in order to replicate the properties of biological membranes [ 23 , 24 , 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Agarose as a Tissue Mimic for the Porcine Heart, Kidney, and Liver: Measurements and a Springpot Model

Mishra,

Cleveland

2024

Bioengineering

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Agarose gels are often used as a tissue mimic. The goal of this work was to determine the appropriate agarose concentrations that result in mechanical properties that match three different porcine organs. Strain tests were carried out with an amplitude varying from 0.01% to 10% at a frequency of 1 Hz on a range of agarose concentrations and porcine organs. Frequency sweep tests were performed from 0.1 Hz to a maximum of 9.5 Hz at a shear strain amplitude of 0.1% for agarose and porcine organs. In agarose samples, the effect of pre-compression of the samples up to 10% axial strain was considered during frequency sweep tests. The experimental measurements from agarose samples were fit to a fractional order viscoelastic (springpot) model. The model was then used to predict stress relaxation in response to a step strain of 0.1%. The prediction was compared to experimental relaxation data, and the results agreed within 12%. The agarose concentrations (by mass) that gave the best fit were 0.25% for the liver, 0.3% for the kidney, and 0.4% for the heart. At a frequency of 0.1 Hz and a shear strain of 0.1%, the agarose concentrations that best matched the shear storage modulus of the porcine organs were 0.4% agarose for the heart, 0.3% agarose for the kidney, and 0.25% agarose for the liver.

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Section: Introductionmentioning

confidence: 99%

Agarose as a Tissue Mimic for the Porcine Heart, Kidney, and Liver: Measurements and a Springpot Model

Mishra,

Cleveland

2024

Bioengineering

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Analyzing the effects of printing parameters to minimize the dimensional deviation of polylactic acid parts by applying three different decision-making approaches

Solouki,

Aliha,

Makui

et al. 2024

Sci Rep

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This article examines the influence of various factors on the precision of 3D printed objects produced through Fused Filament Fabrication (FFF) using Polylactic Acid (PLA) as the primary material. While PLA is widely chosen for its compatibility with biological applications, it does suffer from limited dimensional accuracy. The study focuses on investigating the effects of four independent parameters, namely layer height, infill density, printing speed, and the number of top and bottom layers, on accuracy along the three axes of length, width, and depth. The research objective is to identify the optimal levels of these parameters that minimize dimensional errors across all axes. However, due to conflicting requirements among different dimensions, determining a comprehensive decision-making methodology presents a significant challenge. To address this issue, three distinct approaches are proposed, each offering a unique perspective and practical application. Interestingly, the outcomes of these approaches converge on a single solution. Among these parameters, printing speed emerges as the dominant factor, while, the number of layers is the least influential. Moreover, consistent shrinkage is observed in the length and width dimensions, with greater errors evident in longer dimensions. Overall, a preference for lower layer height and infill density, along with higher printing speed and increased top and bottom layers, is recommended. The study findings indicate that the most effective parameter selection for reducing errors in all dimensions involves a layer height of 0.2 mm, infill density of 60%, printing speed of 50 mm/s, and the use of four top and bottom layers.

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DEIT-Based Bone Position and Orientation Estimation for Robotic Support in Total Knee Arthroplasty—A Computational Feasibility Study

Schrott,

Affortunati,

Stadler

et al. 2024

Sensors

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Total knee arthroplasty (TKA) is a well-established and successful treatment option for patients with end-stage osteoarthritis of the knee, providing high patient satisfaction. Robotic systems have been widely adopted to perform TKA in orthopaedic centres. The exact spatial positions of the femur and tibia are usually determined through pinned trackers, providing the surgeon with an exact illustration of the axis of the lower limb. The drilling of holes required for mounting the trackers creates weak spots, causing adverse events such as bone fracture. In the presented computational feasibility study, time differential electrical impedance tomography is used to locate the femur positions, thereby the difference in conductivity distribution between two distinct states s0 and s1 of the measured object is reconstructed. The overall approach was tested by simulating five different configurations of thigh shape and considered tissue conductivity distributions. For the cylinder models used for verification and reference, the reconstructed position deviated by about ≈1 mm from the actual bone centre. In case of models mimicking a realistic cross section of the femur position deviated between 7.9 mm 24.8 mm. For all models, the bone axis was off by about φ=1.50° from its actual position.

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A novel two-dimensional phantom for electrical impedance tomography using 3D printing

Cited by 3 publications

References 26 publications

Agarose as a Tissue Mimic for the Porcine Heart, Kidney, and Liver: Measurements and a Springpot Model

Agarose as a Tissue Mimic for the Porcine Heart, Kidney, and Liver: Measurements and a Springpot Model

Analyzing the effects of printing parameters to minimize the dimensional deviation of polylactic acid parts by applying three different decision-making approaches

DEIT-Based Bone Position and Orientation Estimation for Robotic Support in Total Knee Arthroplasty—A Computational Feasibility Study

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