A novel uncoupled quasi-3D Euler-Euler model to study the spiral jet mill micronization of pharmaceutical substances at process scale: model development and validation

Sabia, Carmine; Casalini, Tommaso; Cornolti, Luca; Spaggiari, Marco; Frigerio, Giovanni; Martinoli, Luca; Martinoli, Alberto; Buffo, Antonio; Marchisio, Daniele; Barbato, Maurizio

doi:10.1016/j.powtec.2022.117573

Cited by 5 publications

(3 citation statements)

References 20 publications

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“…In the present study, the commercial CFD software Fluent 2022 is used for the prediction of flow fields. The standard k-epsilon turbulence model is chosen, which is widely used in the field of fluidized bed opposed jet mills [32], and the SIMPLE algorithm is adopted as the velocity-pressure decoupling algorithm. The simulation considers flow within a circular pipe, with the actual diameter defined as the hydraulic diameter, and the rotational speed of the classifier wheel is set at 5000 rpm.…”

Section: Simulation Conditions and Coupling Modelsmentioning

confidence: 99%

Research on the Grinding Process of Superhard Particles in the Fluidized Bed Opposed Jet Mill Based on the CFD-DEM Methodology

Shen,

Jiang,

Liu

et al. 2024

Minerals

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The process of superhard particle breakage in the grinding zone of the fluidized bed opposed jet mill is investigated using the CFD-DEM (computational fluid dynamics-discrete element method) coupling method with the Tavares UFRJ Breakage Model in the present study. The effects of structural and operational parameters, such as target plate structure, nozzle position, air inlet velocity, and feed rate, on the equipment stress distribution, airflow velocity, pressure field, particle velocity, and cumulative particle size distribution are thoroughly studied to determine the optimal structural and operational parameters. Experimental validation is conducted, including scanning electron microscope (SEM) observation of particle morphology and analysis of particle size distribution of ground product particles. The simulation results indicate that the wear rate of the structure without a target plate is lower than that of the structure with a target plate in the grinding central zone. Therefore, the structure without a target plate is chosen for further investigation. The cumulative particle size distribution after grinding is influenced by nozzle position, air inlet velocity, and feed rate. The particle D50 is positively correlated with nozzle spacing and feed rate, while it is negatively correlated with air inlet velocity. The optimal grinding effect is achieved when the distance between the nozzle and the center of the grinding zone ranges from 52.5 mm to 72.55 mm, the air inlet velocity is 950 m/s, and the feed rate is 10.5 g/s. Through experimental investigation, it has been observed that when the feed rate is 10 g/s, the particle size distribution becomes more uniform. Furthermore, consistent trends in the cumulative particle size distribution in the experiment and simulation results can be found, which validates the present numerical model. It was observed that particles at low feed rates retain certain angular edges, while particle roundness increases at high feed rates.

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Section: Simulation Conditions and Coupling Modelsmentioning

confidence: 99%

Research on the Grinding Process of Superhard Particles in the Fluidized Bed Opposed Jet Mill Based on the CFD-DEM Methodology

Shen,

Jiang,

Liu

et al. 2024

Minerals

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“…Since classification only occurs near the top and bottom walls, making it difficult for large particles to obtain large impact energy in such flow fields [1][2][3]. Carmine et al presented a novel approach to model the micronization of pharmaceutical ingredients at process scales and times, and the proposed approach could be used to estimate the outlet particle size distribution in a short computational time [4]. Researchers have also pointed out in some studies that superheated steam has excellent particle crushing performance, which can avoid the problem of excessive impurities and large particles caused by metal grinding mill [5].…”

Section: Introductionmentioning

confidence: 99%

CFD simulation of flyash fluidized-bed pulverization with superheated steam

Zhang,

Hong,

Liu

et al. 2024

J. Phys.: Conf. Ser.

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The supersonic pulverization technology uses superheated steam generated by the boiler to generate supersonic airflow through the Laval nozzle, and accelerates the flyash fed into the crushing chamber by the screw feeder, and then the flyash can be crushed in mutual collision and friction process. The present paper conducted CFD simulation of fluidized-bed pulverization with superheated steam, and both the velocity filed and the particle tracks are obtained. Convergence test was performed firstly to verify the numerical results, and three different meshes and several different numbers of particles are employed here to show the average velocity of the particles through a certain horizontal plane. The effect of some key parameters, such as distance between the two opposite nozzles and feeding locations of the flyash to the velocity filed and the particle velocity are also numerically investigated. Results show that, the best distance between the two opposite nozzles of the four-nozzle case is 142 mm and the average particle velocity distribution varies little with the flyash feeding position for the present jet mill model.

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“…For instance, in aquatic systems, the breakup of plastic waste governs the rate of microparticle production and, as such, plays a key role on the microplastics rate of release in the ocean (Garvey et al, 2020;Poulain et al, 2018;Brouzet et al, 2021). In some pharmaceutical applications, active particles are in need to be reduced in size before administration can take place (Capecelatro et al, 2022;Sabia et al, 2022;Vasquez Giuliano et al, 2022), and in polymer compounding processes, controlled breakup and redistribution of filler agglomerates is used to produce composites with enhanced mechanical and/or thermal properties (Frungieri et al, 2020b(Frungieri et al, , 2022.…”

Section: Introductionmentioning

confidence: 99%

Heavy and light inertial particle aggregates in homogeneous isotropic turbulence: A study on breakup and stress statistics

Frungieri¹,

Baebler²,

Biferale³

et al. 2022

Preprint

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The breakup of inertial, solid aggregates in an incompressible, homogeneous and isotropic three-dimensional turbulent flow is studied by means of a direct numerical simulation, and by a Lagrangian tracking of the aggregates at varying Stokes number and fluid-to-particle density ratio. Within the point-particle approximation of the Maxey-Riley-Gatignol equations of motion, we analyse the statistics of the time series of shear and drag stresses, which are here both deemed as responsible for particle breakup. We observe that, regardless of the Stokes number, the shear stresses produced by the turbulent velocity gradients similarly impact the breakup statistics of inertial and neutrally buoyant aggregates, and dictate the breakup rate of loose aggregates. When the density ratio is different from unity, drag stresses become dominant and are seen to be able to cause to breakup of also the most resistant aggregates. The present work paves the way for including the role of inertia in population balance models addressing particle breakup in turbulent flows.

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A novel uncoupled quasi-3D Euler-Euler model to study the spiral jet mill micronization of pharmaceutical substances at process scale: model development and validation

Cited by 5 publications

References 20 publications

Research on the Grinding Process of Superhard Particles in the Fluidized Bed Opposed Jet Mill Based on the CFD-DEM Methodology

Research on the Grinding Process of Superhard Particles in the Fluidized Bed Opposed Jet Mill Based on the CFD-DEM Methodology

CFD simulation of flyash fluidized-bed pulverization with superheated steam

Heavy and light inertial particle aggregates in homogeneous isotropic turbulence: A study on breakup and stress statistics

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