A crucial area of study in data mining is outlier detection, particularly in the areas of network security, credit card fraud detection, industrial flaw detection, etc. Existing outlier detection algorithms, which can be divided into supervised methods, semi-supervised methods, and unsupervised methods, suffer from missing labeled data, the curse of dimensionality, low interpretability, etc. To address these issues, in this paper, we present an unsupervised outlier detection method based on quantiles and skewness coefficients called ISOD (Interpretable Single dimension Outlier Detection). ISOD first fulfils the empirical cumulative distribution function before computing the quantile and skewness coefficients of each dimension. Finally, it outputs the outlier score. This paper’s contributions are as follows: (1) we propose an unsupervised outlier detection algorithm called ISOD, which has high interpretability and scalability; (2) massive experiments on benchmark datasets demonstrated the superior performance of the ISOD algorithm compared with state-of-the-art baselines in terms of ROC and AP.