A novel varicella-zoster virus gE mutation discovered in two Swedish isolates

Wirgart, Benita Zweygberg; Estrada, Víctor Fernando Muñoz; Jackson, Wallen; Linde, Annika; Grose, Charles

doi:10.1016/j.jcv.2006.06.007

Cited by 18 publications

(8 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The finding that a mutation can occur in a B cell epitope on a major surface gE protein is important because of the possibility that the loss of an epitope represents an escape mutation from the immune response induced by most wild-type isolates or, possibly, varicella vaccination. To date, the gE mutations have been found only in strains from Europe and North America [11]. In 2006, a virus bearing a gE mutation in a region associated with greater viral spread [21] and important for the formation a B cell epitope [8] was found to be the cause of a fatal case of hepatitis in an immunocompetent child [12].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparative Analyses of the 9 Glycoprotein Genes Found in Wild‐Type and Vaccine Strains of Varicella‐Zoster Virus

et al. 2008

Self Cite

View full text Add to dashboard Cite

The complete DNA sequences of wild-type and vaccine strains of varicella-zoster virus have been published and listed in GenBank. In this comparative genomic analysis, the sequences of the 9 glycoprotein open reading frames (ORFs) were compared. They included gE (ORF68), gI (ORF 67), gC (ORF14), gH (ORF37), gL (ORF60), gB (ORF31), gK (ORF5), gM (ORF50), and gN (ORF8 or ORF9A). After realignment on the basis of newer data, the corrected gB sequence was lengthened to include 931 residues. The data showed that there were glycoprotein polymorphisms that differentiated North American/European strains from Japanese strains-for example, an additional ATG codon in the gL of all Oka strains. Also, there were a small number of coding single-nucleotide polymorphisms present only in glycoproteins of vaccine strains. Because these changes were highly conserved, the structure of the glycoprotein was unlikely to be altered.

show abstract

Section: Discussionmentioning

confidence: 99%

“…The first 2 viruses were discovered in Minneapolis, Minnesota, and Vancouver, British Columbia (figure 1). The second 2 were discovered in Stockholm, Sweden, by Wirgart et al [11]. The fifth was isolated from a child with varicella in Rome, Italy [12].…”

mentioning

confidence: 97%

Comparative Analyses of the 9 Glycoprotein Genes Found in Wild‐Type and Vaccine Strains of Varicella‐Zoster Virus

et al. 2008

Self Cite

View full text Add to dashboard Cite

show abstract

“…The Canadian case involved an elderly man with zoster, a fact which indicates that the mutant virus would have been present about 50 years earlier (around the year 1950), when the man had chickenpox as a child. Subsequently, stored VZV isolates from the Karolinska University Hospital in Stockholm, Sweden, were examined, and two gE mutant viruses were discovered (56). Finally, a gE mutant virus was isolated from a child with fatal varicella in Rome, Italy (36).…”

Section: Vzv Genotypes With New Phenotypesmentioning

confidence: 99%

Pangaea and the Out-of-Africa Model of Varicella-Zoster Virus Evolution and Phylogeography

Grose

2012

J Virol

Self Cite

View full text Add to dashboard Cite

The goal of this minireview is to provide an overview of varicella-zoster virus (VZV) phylogenetics and phylogeography when placed in the broad context of geologic time. Planet Earth was formed over 4 billion years ago, and the supercontinent Pangaea coalesced around 400 million years ago (mya). Based on detailed tree-building models, the base of the phylogenetic tree of theHerpesviridaefamily has been estimated at 400 mya. Subsequently, Pangaea split into Laurasia and Gondwanaland; in turn, Africa rifted from Gondwanaland. Based on available data, the hypothesis of this minireview is that the ancestral alphaherpesvirus VZV coevolved in simians, apes, and hominins in Africa. When anatomically modern humans first crossed over the Red Sea 60,000 years ago, VZV was carried along in their dorsal root ganglia. Currently, there are five VZV clades, distinguishable by single nucleotide polymorphisms. These clades likely represent continued VZV coevolution, as humans with latent VZV infection left Arabia and dispersed into Asia (clades 2 and 5) and Europe (clades 1, 3, and 4). The prototype VZV sequence contains nearly 125,000 bp, divided into 70 open reading frames. Generally, isolates within a clade display >99.9% identity to one another, while members of one clade compared to a second clade show 99.8% identity to one another. Recently, four different VZV genotypes that do not segregate into the previously defined five clades have been identified, a result indicating a wider than anticipated diversity among newly collected VZV strains around the world.

show abstract

“…This mutation has now been detected in two patients, one in the US and one in Canada (Santos et al 2000;Tipples et al 2002). In addition two isolates from leukemic children in Sweden were found to have different mutation in gE, S152A, which also abrogated binding of the antibody (Wirgart et al 2006). Finally, a fatal case of varicella in a 15-year-old Italian boy was caused by a virus with a mutation in the terminal amino acid of gE, G161R, though it is not known whether this mutation also affected antibody binding.…”

Section: Genotyping and Virulencementioning

confidence: 96%

VZV Molecular Epidemiology

Breuer

2010

Current Topics in Microbiology and Immunology

View full text Add to dashboard Cite

The molecular epidemiology of varicella zoster virus (VZV) has led to an understanding of virus evolution, spread, and pathogenesis. The availability of over 20 full length genomes has confirmed the existence of at least five virus clades and generated estimates of VZV evolution, with evidence of recombination both past and ongoing. Genotyping by restriction enzyme analysis (REA) and single nucleotide polymorphisms (SNP) has proven that the virus causing varicella is identical to that which later reactivates as zoster in an individual. Moreover, these methods have shown that reinfection, which is mostly asymptomatic, may also occur and the second virus may establish latency and reactivate. VZV is the only human herpesvirus that is spread by the respiratory route. Genotyping methods, together with epidemiological data and modeling, have provided insights into global differences in the transmission patterns of this ubiquitous virus.

show abstract

A novel varicella-zoster virus gE mutation discovered in two Swedish isolates

Cited by 18 publications

References 14 publications

Comparative Analyses of the 9 Glycoprotein Genes Found in Wild‐Type and Vaccine Strains of Varicella‐Zoster Virus

Comparative Analyses of the 9 Glycoprotein Genes Found in Wild‐Type and Vaccine Strains of Varicella‐Zoster Virus

Pangaea and the Out-of-Africa Model of Varicella-Zoster Virus Evolution and Phylogeography

VZV Molecular Epidemiology

Contact Info

Product

Resources

About