A novel voltammetric sensor for ascorbic acid based on molecularly imprinted poly(o-phenylenediamine-co-o-aminophenol)

Kong, Yong; Shan, Xueling; Ma, Jianfeng; Chen, Meilan; Chen, Zhidong

doi:10.1016/j.aca.2013.12.003

Cited by 59 publications

(26 citation statements)

References 34 publications

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“…Compared with a polypyrrole-based sensor for ascorbic acid (concentrations ranging from 250 to 7000 μM and LOD of 74 μM), the analytical performance of the imprinted copolymer sensor was enhanced (concentrations ranging between 100 and 10,000 μM, and an LOD of 50 μM). This is attributed to the broadened usable pH range of poly(o-phenylenediamine-co-oaminophenol) (from pH 1.0 to pH 8.0) [52]. The sensor also showed good reproducibility and stability, and it has been successfully used to determine ascorbic acid in real samples.…”

Section: Nature Of Recognition Elementmentioning

confidence: 99%

“…This indicates that the molecularly imprinted polymer significantly absorbs propylparaben from the aqueous solution, compared with the non-imprinted polymer-based sensor [51]. In another work, Kong et al [52] fabricated an electrochemical sensor for ascorbic acid using a molecularly imprinted copolymer, poly(o-phenylenediamine-co-oaminophenol) as the recognition element, noting a high sensitivity and selectivity. Compared with a polypyrrole-based sensor for ascorbic acid (concentrations ranging from 250 to 7000 μM and LOD of 74 μM), the analytical performance of the imprinted copolymer sensor was enhanced (concentrations ranging between 100 and 10,000 μM, and an LOD of 50 μM).…”

Section: Nature Of Recognition Elementmentioning

confidence: 99%

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Critical overview on the application of sensors and biosensors for clinical analysis

Justino

Duarte

Rocha-Santos

2016

TrAC Trends in Analytical Chemistry

133

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A B S T R A C TSensors and biosensors have been increasingly used for clinical analysis due to their miniaturization and portability, allowing the construction of diagnostic devices for point-of-care testing. This paper presents an up-to-date overview and comparison of the analytical performance of sensors and biosensors recently used in clinical analysis. This includes cancer and cardiac biomarkers, hormones, biomolecules, neurotransmitters, bacteria, virus and cancer cells, along with related significant advances since 2011. Some methods of enhancing the analytical performance of sensors and biosensors through their figures of merit are also discussed.

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Section: Nature Of Recognition Elementmentioning

confidence: 99%

Section: Nature Of Recognition Elementmentioning

confidence: 99%

Critical overview on the application of sensors and biosensors for clinical analysis

Justino

Duarte

Rocha-Santos

2016

TrAC Trends in Analytical Chemistry

133

View full text Add to dashboard Cite

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“…The selectivity of the (MIP‐CPE) was examined in the presence of several interfering substances of close structure to VCV and excipients. Cyclic voltammograms for a 5.0x10 −5 M solution of VCV were recorded in the absence and the presence of different concentrations (5.0x10 −5 , 5.0x10 −4 and 5.0x10 −3 M) of the interfering substances . The results are shown in Table .…”

Section: Resultsmentioning

confidence: 93%

Voltammetric Determination of Valaciclovir Using a Molecularly Imprinted Polymer Modified Carbon Paste Electrode

et al. 2017

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A molecularly imprinted polymer (MIP) was rationally synthesized with the aid of computer based studies. The computational studies were used to screen for the most suitable template to functional monomer molar ratio. Two functional monomers were involved in the study (methacrylic acid and 4‐vinylpyridine). Four MIP ratios were synthesized in accordance with the results of the computational studies and their performance was evaluated using equilibrium rebinding assays. The MIP with the best performance was used as an additive in carbon paste electrodes for the voltammetric determination of valaciclovir (VCV). Following the optimization of voltammetric parameters, a linear response was obtained in the range of 1.0x10−6–7.0x10−4 M with a limit of detection at 4.45x10−7 M. The MIP modified carbon paste electrode was successfully applied for the determination of VCV in pure solutions and dosage form.

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“…This decrease in the peak currents at the alginate modified GCE lies in the fact that the alginate is negatively charged species, and it would repel the anions of Fe(CN) 6 4-/3− during the cyclic voltammetric measurements. EIS can provide useful information concerning the electrode-solution interfacial properties, 26,27 and the Nyquist plots of bare GCE and SA/GCE in 0.1 M KCl solution containing 5 mM Fe(CN) 6 4-/3− are shown in Figure 2B, in which the experimental data were analyzed by the Zview modeling software according to the equivalent circuit. The first intercept of the semicircle on the real axis represents the value of electrolyte resistance (R s ).…”

Section: Resultsmentioning

confidence: 99%

Electrochemical Recognition of Tyrosine Enantiomers Based on Chiral Ligand Exchange with Sodium Alginate as the Chiral Selector

Bao

Dai

Yang

et al. 2015

J. Electrochem. Soc.

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Enantiorecognition of tyrosine (Tyr) enantiomers is realized via chiral ligand exchange technology combined with electrochemistry. A natural polymer, sodium alginate (SA), is electrodeposited on a glassy carbon electrode (GCE) and adopted as the chiral selector to form a diastereoisomeric ternary complex of [(SA)Zn(II)(L-Tyr)] or [(SA)Zn(II)(D-Tyr)] in the presence of Zn(II). Due to the difference in steric hindrance during the formation of these two complexes, the chiral selector preferentially recognizes D-Tyr. The electrochemical enantiorecognition of Tyr enantiomers is characterized by cyclic voltammetry and electrochemical impedance spectroscopy (EIS), and the parameters affecting the recognition efficiency are also investigated.Enantioselective recognition of chiral compounds is of great importance for the food and medical industry, because the enantiomers of a chiral molecule may exhibit different or even opposite biological activities. 1,2 Current enantiomer recognition approaches mainly include molecular imprinting, 3,4 host-guest supramolecular chemistry, 5-7 and chiral ligand exchanging. 8,9 The principle of chiral ligand exchange is based on the diastereomeric ternary coordination formatted by chiral selector, metal ion and analyte. The commonly used chiral selectors in ligand exchange are one of the optical isomers of amino acids 10,11 or their derivatives 12,13 and bovine serum albumin (BSA), 14 however, large scale application has been precluded due to its prohibitive costs and vulnerability of amino acids and proteins denaturation under harsh conditions. Sodium alginate (SA), a polysaccharide from seaweeds, is a biocompatible, biodegradable, non-toxic and non-immunogenic natural polymer with natural chiral environment, 15 and SA and its composites have been widely used as food additives in food industry. [16][17][18] Recently, the inherent chirality of SA was utilized for selective separation of phenylalanine isomers via molecularly imprinted SA-based hybrid membranes, 19 showing the potential applications of SA as an excellent candidate in chiral recognition. Moreover, among the industrially attractive polysaccharide polymers, alginate is known to have high complex formation ability with various heavy metals such as Co(II) and Zn(II). 20,21 And therefore it strongly attracts us to apply SA as the chiral selector to form a diastereomeric ternary complex with metal ion and analyte for enantioselective recognition purpose, taking its natural chirality and strong coordination ability into account.Herein, we report on the electrochemical chiral recognition of tyrosine (Tyr) enantiomers via ligand exchange technology using SA as the chiral selector in the presence of Zn(II). Tyr isomers are chosen as the target molecules owing to their good electroactivity and great importance for human and herbivores bodies, 22,23 meanwhile, amino acids can form metal complexes with metal ions. 24,25 In this work, the complexes of Zn(II) and Tyr isomers are denoted as Zn(II)(LTyr) 2 and Zn(II)(D-Tyr) 2 since one Zn(II...

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A novel voltammetric sensor for ascorbic acid based on molecularly imprinted poly(o-phenylenediamine-co-o-aminophenol)

Cited by 59 publications

References 34 publications

Critical overview on the application of sensors and biosensors for clinical analysis

Critical overview on the application of sensors and biosensors for clinical analysis

Voltammetric Determination of Valaciclovir Using a Molecularly Imprinted Polymer Modified Carbon Paste Electrode

Electrochemical Recognition of Tyrosine Enantiomers Based on Chiral Ligand Exchange with Sodium Alginate as the Chiral Selector

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