A nucleobase-inspired super adhesive hydrogel with desirable mechanical, tough and fatigue resistant properties based on cytosine and ε-caprolactone

Zhang, Xiaoyong; Wang, Duo; Liu, Huihui; Yue, Lipei; Bai, Yongping; He, Jinmei

doi:10.1016/j.eurpolymj.2020.109741

Cited by 13 publications

(6 citation statements)

References 39 publications

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“…The Fourier transform infrared spectroscopy (FT-IR) spectra of the washed gel also supports the complete removal of GA; the IR details are briefly explained in “ Characterization of GbH ” section. The stickiness of the GbH to the wet surface is enabled by the surface amine groups present on the hydrogel 27 , 28 . The GbH was kept on diverse surfaces (overnight at RT) and the stickiness of each hydrogel to the surface was observed (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…2 e), indicating the abundance of hydrophilic O–H groups contributed by its components. Research indicates that the adhesives characteristics of hydrogels are mainly associated with the surface O–H groups of the hydrogel interacting with chemical groups such as hydroxyl, amino, and carboxyl on the surface of tissues 27 , 28 , 35 . The peak at 1141 cm −1 revealed C–O stretching arising due to the intermolecular hydrogen bonds formed between neighbouring PVA chains 36 .…”

Section: Resultsmentioning

confidence: 99%

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Bioinspired gelatin based sticky hydrogel for diverse surfaces in burn wound care

George

Bhatia

Kumar

et al. 2022

Sci Rep

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Proper burn wound management considers patient’s compliance and provides an environment to accelerate wound closure. Sticky hydrogels are conducive to wound management. They can act as a preventive infection patch with controlled drug delivery and diverse surface adherence. A hypothesis-driven investigation explores a bioinspired polydopamine property in a gelatin-based hydrogel (GbH) where polyvinyl alcohol and starch function as hydrogel backbone. The GbH displayed promising physical properties with O–H group rich surface. The GbH was sticky onto dry surfaces (glass, plastic and aluminium) and wet surfaces (pork and chicken). The GbH demonstrated mathematical kinetics for a transdermal formulation, and the in vitro and in vivo toxicity of the GbH on test models confirmed the models’ healthy growth and biocompatibility. The quercetin-loaded GbH showed 45–50% wound contraction on day 4 for second-degree burn wounds in rat models that were equivalent to the silver sulfadiazine treatment group. The estimates for tensile strength, biochemicals, connective tissue markers and NF-κB were restored on day 21 in the GbH treated healed wounds to imitate the normal level of the skin. The bioinspired GbH promotes efficient wound healing of second-degree burn wounds in rat models, indicating its pre-clinical applicability.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Bioinspired gelatin based sticky hydrogel for diverse surfaces in burn wound care

George

Bhatia

Kumar

et al. 2022

Sci Rep

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“…Nucleobase-containing polymers bearing specific hydrogen bonding recognition are a crucial design feature for tailoring supramolecular TPE properties [10]. In addition to the incorporation of thermo-and solvent-reversible crosslinks [11][12][13][14], the presence of nucleobase sites in TPEs afford novel properties such as self-healing and shape memory [15][16][17]. The physical properties of a nucleobase-functionalized polymer strongly depend on the association strength of nucleobases.…”

Section: Introductionmentioning

confidence: 99%

Quadruple Hydrogen Bond-Containing A-AB-A Triblock Copolymers: Probing the Influence of Hydrogen Bonding in the Central Block

et al. 2021

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This work reveals the influence of pendant hydrogen bonding strength and distribution on self-assembly and the resulting thermomechanical properties of A-AB-A triblock copolymers. Reversible addition-fragmentation chain transfer polymerization afforded a library of A-AB-A acrylic triblock copolymers, wherein the A unit contained cytosine acrylate (CyA) or post-functionalized ureido cytosine acrylate (UCyA) and the B unit consisted of n-butyl acrylate (nBA). Differential scanning calorimetry revealed two glass transition temperatures, suggesting microphase-separation in the A-AB-A triblock copolymers. Thermomechanical and morphological analysis revealed the effects of hydrogen bonding distribution and strength on the self-assembly and microphase-separated morphology. Dynamic mechanical analysis showed multiple tan delta (δ) transitions that correlated to chain relaxation and hydrogen bonding dissociation, further confirming the microphase-separated structure. In addition, UCyA triblock copolymers possessed an extended modulus plateau versus temperature compared to the CyA analogs due to the stronger association of quadruple hydrogen bonding. CyA triblock copolymers exhibited a cylindrical microphase-separated morphology according to small-angle X-ray scattering. In contrast, UCyA triblock copolymers lacked long-range ordering due to hydrogen bonding induced phase mixing. The incorporation of UCyA into the soft central block resulted in improved tensile strength, extensibility, and toughness compared to the AB random copolymer and A-B-A triblock copolymer comparisons. This study provides insight into the structure-property relationships of A-AB-A supramolecular triblock copolymers that result from tunable association strengths.

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“…The good adhesiveness of the CCNF-LM-PAA hydrogel to various substrates is attributed to its combined performance in forming chemical bonds and a mechanical interlock with joint surfaces, as well as energy dissipation in deformation [46]. The CCNF-LM-PAA hydrogel can form hydrogen bonds, ionic coordination, and ion-dipole/electrostatic interactions with various substrate interfaces because of the presence of Ga 3+ and numerous functional groups, such as carboxyl, hydroxyl, and quaternary ammonium groups, in the hydrogel [52,53]. The formation of a mechanical interlock with rough surfaces originates from the good moldability of the CCNF-LM-PAA hydrogel, which can fill the pits before gelatinization.…”

Section: Resultsmentioning

confidence: 99%

Highly sensitive and self-healing conductive hydrogels fabricated from cationic cellulose nanofiber-dispersed liquid metal for strain sensors

Wang

Chen

et al. 2023

Sci. China Mater.

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The emergence of liquid metal (LM) emulsion as a soft multifunctional filler brings a new opportunity for fabricating hydrogel-based strain sensors with multifunctional properties. However, the extremely large surface tension and high density of LMs inhibit emulsification. Herein, we demonstrated a strategy for stabilizing LM emulsions using cationic cellulose nanofibers (CCNFs) to encapsulate LM droplets through strong electrostatic attraction with LM. By inducing acrylic acid (AA) polymerization in the presence of a CCNF-stabilized LM emulsion, a conductive hydrogel was prepared with the formation of reversible hydrogen bonds, ionic coordination, and electrostatic interactions among CCNFs, LM droplets, and poly(acrylic acid) (PAA). The hydrogel obtained, named the CCNF-LM-PAA hydrogel, shows good conductivity (1.54 S m −1 ), remarkable tensile strength and elongation at break, self-adhesiveness, and quick self-healing capability. As a strain-sensing material, the CCNF-LM-PAA hydrogel exhibits a very high sensing sensitivity (gauge factor = 16.2), a low strain detection limit (less than 1%), a short response/recovery time (107/91 ms), and good durability (300 cycles). These results enable the CCNF-LM-PAA hydrogel-based strain sensor to be an excellent wearable device for monitoring various human activities. Therefore, introducing additional electrostatic interactions by using CCNFs to stabilize LM emulsions provides a practical way to enhance the strain-sensing performance of LM emulsion-based hydrogels for assembling selfattached wearable devices.

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A nucleobase-inspired super adhesive hydrogel with desirable mechanical, tough and fatigue resistant properties based on cytosine and ε-caprolactone

Cited by 13 publications

References 39 publications

Bioinspired gelatin based sticky hydrogel for diverse surfaces in burn wound care

Bioinspired gelatin based sticky hydrogel for diverse surfaces in burn wound care

Quadruple Hydrogen Bond-Containing A-AB-A Triblock Copolymers: Probing the Influence of Hydrogen Bonding in the Central Block

Highly sensitive and self-healing conductive hydrogels fabricated from cationic cellulose nanofiber-dispersed liquid metal for strain sensors

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