The current study investigates mixed convective flow of an unsteady MHD tangent hyperbolic nanofluid due to a stretching surface with motile microorganisms via convective heat transfer and slip conditions. The flow analysis's governing equations were converted into a nondimensional relation by using the proper alteration. The pertinent similarity transformations are utilized in the main equations, and the solutions are obtained using the integrated bvp4c software. A good agreement with previously published data indicates the efficacy of the numerical technique. The following are the main findings: increasing the magnitude of the radiation and mixed convection parameters improves the velocity profile, whereas the Weissenberg number and magnetic field demonstrate the opposite influence; improvements in heat transfer occur due to the thermal radiation parameter, Brownian movement, and thermophoretic effects; activation energy improves concentration profile, whereas Lewis number shows opposite effect; bioconvection Lewis number and Peclet number declines the Motile microorganism density. Additionally, a tabular analysis of the skin friction, motile microorganism density, Nusselt number, and Sherwood number is also provided.