Volume 3B: Biomedical and Biotechnology Engineering 2013
DOI: 10.1115/imece2013-63916
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A Numerical Investigation of the Fluid Flow in a Chandler Loop for Thrombus Studies

Abstract: The Chandler loop is an artificial circulatory platform for in vitro hemodynamic experiments. In most experiments, the working fluid is subjected to a stress field via rotation of the Chandler loop, which, in turn, induces biochemical responses of the suspended cells. For very low rotation rates, the stress field can be approximated using laminar flow in a straight tube as a model. However, as the rotation rate increases, while still maintaining laminar flow, the effect of the tube curvature causes the stress … Show more

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