A numerical method for resolving finite mixtures of three-dimensional inter-site distance distributions measured by single-molecule localization microscopy
Abstract:Three-dimensional (3D) inter-site distance can be measured by single-molecule localization microscopy. Existing theories and analysis tools for 3D inter-site distance measurement only consider the simplest case where all measured distances are from an identical 3D Rician distribution. There are many problems where the 3D inter-site distance measurement result is made up of multiple components. For example, the measurement of intramolecular distances of deoxyribonucleic acid (DNA) with multiple possible conform… Show more
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