A nutraceutical combination reduces left ventricular mass in subjects with metabolic syndrome and left ventricular hypertrophy: A multicenter, randomized, double-blind, placebo-controlled trial

Mercurio, Valentina; Pucci, Giacomo; Bosso, Giorgio; Fazio, Valeria; Battista, Francesca; Iannuzzi, A.; Brambilla, Nadia; Vitalini, Cristina; D’Amato, Massimo; Giacovelli, Giampaolo; Vaudo, Gaetano; Schillaci, Giuseppe; Galletti, Ferruccio; Bonaduce, Domenico

doi:10.1016/j.clnu.2019.06.026

Cited by 18 publications

(26 citation statements)

References 22 publications

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“…In addition, a phase 2 clinical study (NCT03216811) assessed the efficacy of a nutraceutical compound (3 mg containing fermented red rice) in terms of cholesterol, and endothelial and inflammatory parameters in subjects with hypercholesterolemia and low-to-moderate cardiovascular risk. The findings of a very recent study suggest that BBR may be effective and safe to reduce cardiovascular risk associated with metabolic syndrome ( Mercurio et al, 2020 ).…”

Section: Natural Compounds Enhancing Sirt1 Expression and Activitymentioning

confidence: 99%

SIRT1 Activation by Natural Phytochemicals: An Overview

et al. 2020

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Sirtuins are class III histone deacetylases, whose enzymatic activity is dependent on NAD + as a cofactor. Sirtuins are reported to modulate numerous activities by controlling gene expression, DNA repair, metabolism, oxidative stress response, mitochondrial function, and biogenesis. Deregulation of their expression and/or action may lead to tissue-specific degenerative events involved in the development of several human pathologies, including cancer, neurodegeneration, and cardiovascular disease. The most studied member of this class of enzymes is sirtuin 1 (SIRT1), whose expression is associated with increasing insulin sensitivity. SIRT1 has been implicated in both tumorigenic and anticancer processes, and is reported to regulate essential metabolic pathways, suggesting that its activation might be beneficial against disorders of the metabolism. Via regulation of p53 deacetylation and modulation of autophagy, SIRT1 is implicated in cellular response to caloric restriction and lifespan extension. In recent years, scientific interest focusing on the identification of SIRT1 modulators has led to the discovery of novel small molecules targeting SIRT1 activity. This review will examine compounds of natural origin recently found to upregulate SIRT1 activity, such as polyphenolic products in fruits, vegetables, and plants including resveratrol, fisetin, quercetin, and curcumin. We will also discuss the potential therapeutic effects of these natural compounds in the prevention and treatment of human disorders, with particular emphasis on their metabolic impact.

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Section: Natural Compounds Enhancing Sirt1 Expression and Activitymentioning

confidence: 99%

SIRT1 Activation by Natural Phytochemicals: An Overview

et al. 2020

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“…An additional 7 studies were excluded because of a lack of a controlled design for Armolipid Plus ® administration (n = 3) or lack of blinding (n = 4). Finally, 12 studies were eligible and included in the meta-analysis [26][27][28][29][30][31][32][33][34][35][36][37]. The study selection process is shown in Figure 1.…”

Section: Flow and Characteristics Of The Included Studiesmentioning

confidence: 99%

“…All selected trials were designed with parallel groups and were multicenter [29,35,37] or single-center [26][27][28][30][31][32][33][34]36] clinical studies. Enrolled subjects were patients in primary prevention for CVD [28][29][30]32,36], patients with documented coronary artery disease (CAD) [33], with a metabolic syndrome [26,30,[34][35][36], or with a good status of health [28,37]. The baseline characteristics of the evaluated studies are summarized in Tables 1 and 2.…”

Section: Flow and Characteristics Of The Included Studiesmentioning

confidence: 99%

Efficacy and Safety of Armolipid Plus®: An Updated PRISMA Compliant Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials

et al. 2021

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Armolipid Plus® is a multi-constituent nutraceutical that claims to improve lipid profiles. The aim of this PRISMA compliant systematic review and meta-analysis was to globally evaluate the efficacy and safety of Armolipid Plus® on the basis of the available randomized, blinded, controlled clinical trials (RCTs). A systematic literature search in several databases was conducted in order to identify RCTs assessing the efficacy and safety of dietary supplementation with Armolipid Plus®. Two review authors independently identified 12 eligible studies (1050 included subjects overall) and extracted data on study characteristics, methods, and outcomes. Meta-analysis of the data suggested that dietary supplementation with Armolipid Plus® exerted a significant effect on body mass index (mean difference (MD) = −0.25 kg/m2, p = 0.008) and serum levels of total cholesterol (MD = −25.07 mg/dL, p < 0.001), triglycerides (MD = −11.47 mg/dL, p < 0.001), high-density lipoprotein cholesterol (MD = 1.84 mg/dL, p < 0.001), low-density lipoprotein cholesterol (MD = −26.67 mg/dL, p < 0.001), high sensitivity C reactive protein (hs-CRP, MD = −0.61 mg/L, p = 0.022), and fasting glucose (MD = −3.52 mg/dL, p < 0.001). Armolipid Plus® was well tolerated. This meta-analysis demonstrates that dietary supplementation with Armolipid Plus® is associated with clinically meaningful improvements in serum lipids, glucose, and hs-CRP. These changes are consistent with improved cardiometabolic health.

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“…However, the above-mentioned data are derived from animal experiments, and recent clinical trials have shown that BBR is well tolerated in the human body with only some gastrointestinal side effects ( Zhang et al, 2020c ; Zhao et al, 2021b ). Cardioprotective effects have also been confirmed ( Qing et al, 2018 ; Mercurio et al, 2020 ; Zhao et al, 2021a ). These differences may be related to administration time, concentration, and species.…”

Section: The Admet Properties Of Bbrmentioning

confidence: 86%

Apoptosis Induction, a Sharp Edge of Berberine to Exert Anti-Cancer Effects, Focus on Breast, Lung, and Liver Cancer

et al. 2022

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Cancer is the leading cause of death and one of the greatest barriers to increased life expectancy worldwide. Currently, chemotherapy with synthetic drugs remains one of the predominant ways for cancer treatment, which may lead to drug resistance and normal organ damage. Increasing researches have suggested that apoptosis, a type of programmed cell death, is a promising way for cancer therapy. Furthermore, natural products are important sources for finding new drugs with high availability, low cost and low toxicity. As a well-known isoquinoline alkaloid, accumulating evidence has revealed that berberine (BBR) exerts potential pro-apoptotic effects on multiple cancers, including breast, lung, liver, gastric, colorectal, pancreatic, and ovarian cancers. The related potential signal pathways are AMP-activated protein kinase, mitogen-activated protein kinase, and protein kinase B pathways. In this review, we provide a timely and comprehensive summary of the detailed molecular mechanisms of BBR in treating three types of cancer (breast, lung and liver cancer) by inducing apoptosis. Furthermore, we also discuss the existing challenges and strategies to improve BBR’s bioavailability. Hopefully, this review provides valuable information for the comprehension of BBR in treating three types of cancer and highlight the pro-apoptotic effects of BBR, which would be beneficial for the further development of this natural compound as an effective clinical drug for treating cancers.

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A nutraceutical combination reduces left ventricular mass in subjects with metabolic syndrome and left ventricular hypertrophy: A multicenter, randomized, double-blind, placebo-controlled trial

Cited by 18 publications

References 22 publications

SIRT1 Activation by Natural Phytochemicals: An Overview

SIRT1 Activation by Natural Phytochemicals: An Overview

Efficacy and Safety of Armolipid Plus®: An Updated PRISMA Compliant Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials

Apoptosis Induction, a Sharp Edge of Berberine to Exert Anti-Cancer Effects, Focus on Breast, Lung, and Liver Cancer

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