A Nutritional Requirement for Bromine

Huff, Jesse W.; Bosshardt, D. K.; Miller, Orin P.; Barnes, Richard H.

doi:10.3181/00379727-92-22431

Cited by 23 publications

(6 citation statements)

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“…This indicates that the highest accumulation of Br should have occurred within the thyroid gland, but in this trial the highest accumulation occurred within the kidney. On the other hand, Abelin and Poretti (1952), Bosshardt et al (1956), Huff et al (1956), Mack and Shipley (1952) and Winnek and Smith (1937) could demonstrate no preferential uptake by the thyroid gland. Cole and Patrick (1958) measured the kidney and intestines as the most active organs to have taken up 82 Br after a 2 hour intraperitoneal administration.…”

Section: Discussionmentioning

confidence: 99%

Iodine as an alleviator of bromine toxicity in thyroid, liver and kidney of broiler chickens

Toit

Casey

2012

Livestock Science

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The study pursued the hypothesis that bromine (Br) in drinking water at levels > 0.01 mg Br/L may have detrimental effects on the liver, kidneys and thyroid and the thyroid hormones T 3 and T 4 and that iodine (I) may alleviate the potential hazardous effect of Br. The research was done with mixed Ross broiler chickens over a 42-day post-hatch growth period. The trial design was six treatments, T1: 0 mg Br/L and 0 mg I/L; T2: 1 mg Br/L and 0 mg I/L; T3: 3 mg Br/L and 0 mg I/L; T4: 0 mg Br/L and 0.7 mg I/L; T5: 1 mg Br/L and 0.7 mg I/L; and T6: 3 mg Br/L and 0.7 mg I/L delivered via drinking water and three replicates per treatment with 30 birds per replicate. The effect of Br on T 3 and T 4 levels overall was nonsignificant, but T 3 and T 4 levels decreased between Weeks 4 and 6 with a significant effect at Week 6 on T 3 . Br had an overall effect on the thyroid gland (P = 0.0457), liver (P = 0.0025) and kidney (P = 0.0032), and had accumulated in these three organs. Histopathological assessment showed explicit damage to the livers that received the Br treatments. Iodine (0.07 mg/L) ameliorated the negative effects of high Br (3 mg/L Br) concentration and ingestion.

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Section: Discussionmentioning

confidence: 99%

Iodine as an alleviator of bromine toxicity in thyroid, liver and kidney of broiler chickens

Toit

Casey

2012

Livestock Science

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“…Unfortunately, thyroid tissue in 21-day-old chicks is very diffuse, and we were thus unable to evaluate I or Br levels in the thyroid glands of our chicks. Huff et al (23) produced modest growth depressions in mice by feeding iodinated casein (I level or intake not given), and they observed amelioration of the growth depression when 15 mg Br/kg was added to the diet. Because the voluntary food intake depression in our chicks fed high levels of supplemental I was totally corrected by dietary addition of 50 or 100 mg Br/kg, it is unlikely that palatability (i.e., taste) of the high-I diets had anything to do with the anorexia observed when high levels of I were fed.…”

Section: Excess Iodine Ingestion By Humansmentioning

confidence: 99%

“…There is some evidence that Br may be an essential (Ultra) trace element (23,24). Should this be the case, it is interesting to speculate that the growth depression and neurological roll-over symptoms resulting from excess I ingestion may have been due to an antagonistic effect of excess I on body Br.…”

Section: Excess Iodine Ingestion By Humansmentioning

confidence: 99%

Iodine Toxicity and Its Amelioration

Baker

2004

Exp Biol Med (Maywood)

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Iodine (I) toxicity is rare in animals and humans, but nuclear explosions that give off radioactive I and excessive stable I ingestion in parts of the world where seaweed is consumed represent specialized I toxicity concerns. Chronic overconsumption of I reduces organic binding of I by the thyroid gland, which results in hypothyroidism and goiter. Bromine can replace I on position 5 of both T(3) and T(4) with no loss of thyroid hormone activity. Avian work has also demonstrated that oral bromide salts can reverse the malaise and growth depressions caused by high doses of I (as KI) added as supplements to the diet. Newborn infants by virtue of having immature thyroid glands are most susceptible to I toxicity, whether of stable or radioactive origin. For the latter, the 1986 Chernobyl nuclear accident in Belarus has provided evidence that KI blockage therapy for exposed individuals 18 years of age and younger is effective in minimizing the development of thyroid cancer. Whether bromide therapy has a place in I toxicity situations remains to be determined.

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“…Considering health and environmental factors, the rapid selection and sensitive detection of ions have become a research hotspot. , Among the essential trace elements published by the World Health Organization, Fe 3+ ions are the active center of many enzymes and proteins, and its deficiency or excess leads to serious diseases, such as anemia, poor immunity, and cancer. − Therefore, it is urgent to detect Fe 3+ ions with high selectivity. − Br – ions are also beneficial to human health, which has been found and confirmed . Br – ions can inhibit and regulate the activities of the central nervous system or the high-level nervous system in the cerebral cortex . However, excessive intake of Br – ions leads to agglomeration or poisoning .…”

Section: Introductionmentioning

confidence: 99%

Improving Ion Selectivity of 1,4,7-Triazacyclononane-Based Receptor by Zinc Coordination: “Turn-On” Chemosensor for Br^– and Fe³⁺ Ions

et al. 2020

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Ion-responsive probes have gathered significant attention because of health and environmental factors, but there are few reports on the "turn-on" mechanism of Fe 3+ and sensitive detection of Br − by fluorescence measurement. Herein, a green luminescence material, N-5acetyl-2-hydroxy-benzamide-1,4,7-triazacyclononane (btacn), was successfully synthesized for the first time and comprehensively characterized. As expected, btacn exhibits high sensitive, but nonspecific, extensive interaction with Cu 2+ , Co 2+ , Zn 2+ , Mn 2+ , and Fe 3+ ions. Therefore, to improve the specificity of the probe, we tried to synthesize transition metal complexes of btacn, but all failed except Zn(btacn)Cl 2 . In addition, the preformed complex, Zn(btacn)Cl 2 , was used as a special "turn-on" chemosensor for detecting trace amounts of Br − and Fe 3+ . The electrostatic interaction with Fe 3+ and the hydrogen bond of PhO-H•••Br − leads to obvious changes in the electronic cloud of Zn(btacn)Cl 2 , which are reflected in different spectral responses.

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A Nutritional Requirement for Bromine

Cited by 23 publications

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Iodine as an alleviator of bromine toxicity in thyroid, liver and kidney of broiler chickens

Iodine as an alleviator of bromine toxicity in thyroid, liver and kidney of broiler chickens

Iodine Toxicity and Its Amelioration

Improving Ion Selectivity of 1,4,7-Triazacyclononane-Based Receptor by Zinc Coordination: “Turn-On” Chemosensor for Br^– and Fe³⁺ Ions

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A Nutritional Requirement for Bromine

Cited by 23 publications

References 0 publications

Iodine as an alleviator of bromine toxicity in thyroid, liver and kidney of broiler chickens

Iodine as an alleviator of bromine toxicity in thyroid, liver and kidney of broiler chickens

Iodine Toxicity and Its Amelioration

Improving Ion Selectivity of 1,4,7-Triazacyclononane-Based Receptor by Zinc Coordination: “Turn-On” Chemosensor for Br– and Fe3+ Ions

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Product

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Improving Ion Selectivity of 1,4,7-Triazacyclononane-Based Receptor by Zinc Coordination: “Turn-On” Chemosensor for Br^– and Fe³⁺ Ions