2014
DOI: 10.3389/fimmu.2014.00479
|View full text |Cite
|
Sign up to set email alerts
|

“Of Mice and Men”: Arginine Metabolism in Macrophages

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

3
123
1
1

Year Published

2015
2015
2023
2023

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 149 publications
(128 citation statements)
references
References 65 publications
3
123
1
1
Order By: Relevance
“…As mentioned in the Introduction, in vitro human monocyte-derived MFs produce very little NO. Yet, evidence that human tissue MFs make iNOS and NO, both in vivo and ex vivo, suggests that in vitro conditions are missing an essential factor(s) that would enable NO production (3). With the recent work by Mattilla et al (17) demonstrating iNOS and arginase protein expression within human TB granuloma MFs, we expect that competition for L-arginine, which we attempted to model in this work, applies to in vivo pathologies.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…As mentioned in the Introduction, in vitro human monocyte-derived MFs produce very little NO. Yet, evidence that human tissue MFs make iNOS and NO, both in vivo and ex vivo, suggests that in vitro conditions are missing an essential factor(s) that would enable NO production (3). With the recent work by Mattilla et al (17) demonstrating iNOS and arginase protein expression within human TB granuloma MFs, we expect that competition for L-arginine, which we attempted to model in this work, applies to in vivo pathologies.…”
Section: Discussionmentioning
confidence: 99%
“…The contribution of iNOS in human immunity remains less defined than in mice. For instance, many studies showed that human MFs make significantly less NO than do mouse MFs in similar in vitro conditions (3). However, in vivo evidence suggests some protective role for iNOS in human tuberculosis (TB).…”
mentioning
confidence: 99%
“…И эти данные противоречат исследованиям, в которых было показано, что у неинфицированных NOS 2-/-мышей наблюдается дефицит IgA в слизистых и IgG2b в сыворотке. В наивных IgD + B-клетках селезенки, мезентериальных лимфатических узлов или ламина проприа тонкого кишечника iNOS -дефицитных мышей наблюдаются серьез-ные нарушения T-зависимого и T-независимого переключения рекомбинации IgA и продукции IgA [100]. Примечательно, что iNOS не влияет на активацию (эксперессию CD69, MHCII клас-са и CD44) или пролиферацию B-клеток в ответ на ЛПС (T-независимый-антиген) или анти-IgM стимуляцию [91].…”
Section: влияние дефицита аргинина на функции в-лимфоцитовunclassified
“…Whereas these studies used murine macrophages (or human macrophages cultivated at hypoxic conditions [306]), our results from human macrophages incubated in normoxia did not show intracellular tolerance, a finding that we expanded by prolonging antibiotic treatment times and by lowering drug concentrations to the levels inducing tolerance in macrophages in other studies [306,378] (Paper 2, Figure 4). Although expressing iNOS, cultured human macrophages generally produce only small amounts of NO as compared to murine cells [253,408], and evidence exists for a tighter regulation or epigenetic silencing of NO production [254,409]. Several studies suggested a role for NO in human TB [140,255,256], but it is conceivable that NO production in human macrophages requires further activation signals.…”
Section: Intracellular Mtb Phenotype Intracellular Mtb Phenotype Intrmentioning
confidence: 99%
“…Knowledge on NO and iNOS mainly originates from mouse models, as murine macrophages readily produce NO, while NO levels from human macrophages are much lower [253]. Epigenetic silencing of nos2 in human macrophages has been suggested to account for species differences [254].…”
Section: Conditionsmentioning
confidence: 99%