2022
DOI: 10.2460/ajvr.22.11.0194
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A one-health approach to identifying and mitigating the impact of endocrine disorders on human and equine athletes

Abstract: Endocrinopathies affect multiple species in ever-increasing percentages of their populations, creating an opportunity to apply one-health approaches to determining creative preventative measures and therapies in athletes. Obesity and alterations in insulin and glucose dynamics are medical concerns that play a role in whole-body health and homeostasis in both horses and humans. The role and impact of endocrine disorders on the musculoskeletal, cardiovascular, and reproductive systems are of particular interest … Show more

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“…This process is important for normal tissue maintenance and repair and is disordered in disease states where endothelial dysfunction is prevalent [ 1 ]. Despite growing interest in the horse as a large animal model for a range of diseases, including various musculoskeletal conditions [ 2 , 3 , 4 , 5 ], neoplasia [ 6 ], cardiac disease [ 7 ], retinal disease [ 8 ], pulmonary conditions [ 9 , 10 ], endocrinopathies [ 11 ], and Raynaud’s disease [ 12 ], and the recognition that this species has utility for investigating wound healing [ 13 ], regenerative medicine [ 14 , 15 , 16 ], reproductive [ 17 ], immunological [ 18 ], and stem cell [ 16 ] research, alongside the horse’s extreme athletic ability [ 19 ], equine EC biology has received minimal scientific attention.…”
Section: Introductionmentioning
confidence: 99%
“…This process is important for normal tissue maintenance and repair and is disordered in disease states where endothelial dysfunction is prevalent [ 1 ]. Despite growing interest in the horse as a large animal model for a range of diseases, including various musculoskeletal conditions [ 2 , 3 , 4 , 5 ], neoplasia [ 6 ], cardiac disease [ 7 ], retinal disease [ 8 ], pulmonary conditions [ 9 , 10 ], endocrinopathies [ 11 ], and Raynaud’s disease [ 12 ], and the recognition that this species has utility for investigating wound healing [ 13 ], regenerative medicine [ 14 , 15 , 16 ], reproductive [ 17 ], immunological [ 18 ], and stem cell [ 16 ] research, alongside the horse’s extreme athletic ability [ 19 ], equine EC biology has received minimal scientific attention.…”
Section: Introductionmentioning
confidence: 99%