A One Health review of aerodigestive disease in dogs

Grobman, Megan; Reinero, Carol R.

doi:10.1111/jvim.16661

Cited by 4 publications

(1 citation statement)

References 247 publications

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“…Dogs are the animal species described with the highest natural predisposition for the development of HD [ 18 , 83 , 84 ] and, as a result, hold the greatest potential for the identification of equivalent disease loci, homologous genes, and biochemical mechanisms in human developmental HD [ 17 ]. Therefore, the creation of a multidisciplinary consortium between veterinary, human physicians and biologists would allow an exchange of expertise and knowledge in the area of OA [ 17 ], similar to what has already been achieved in other fields [ 165 , 166 ]. Furthermore, veterinary biobanks accept biological samples from osteoarthritic dogs [ 11 ], which later can be used for biomarkers discovery, supporting the use of the dog as the optimal translational model of human HD [ 167 ].…”

Section: Main Textmentioning

confidence: 99%

Mechanical osteoarthritis of the hip in a one medicine concept: a narrative review

Tomé,

Alves-Pimenta,

Sargo

et al. 2023

BMC Vet Res

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Human and veterinary medicine have historically presented many medical areas of potential synergy and convergence. Mechanical osteoarthritis (MOA) is characterized by a gradual complex imbalance between cartilage production, loss, and derangement. Any joint instability that results in an abnormal overload of the joint surface can trigger MOA. As MOA has a prevailing mechanical aetiology, treatment effectiveness can only be accomplished if altered joint mechanics and mechanosensitive pathways are normalized and restored. Otherwise, the inflammatory cascade of osteoarthritis will be initiated, and the changes may become irreversible. The management of the disease using non-steroidal anti-inflammatory drugs, analgesics, physical therapy, diet changes, or nutraceuticals is conservative and less effective. MOA is a determinant factor for the development of hip dysplasia in both humans and dogs. Hip dysplasia is a hereditary disease with a high incidence and, therefore, of great clinical importance due to the associated discomfort and significant functional limitations. Furthermore, on account of analogous human and canine hip dysplasia disease and under the One Medicine concept, unifying veterinary and human research could improve the well-being and health of both species, increasing the acknowledgement of shared diseases. Great success has been accomplished in humans regarding preventive conservative management of hip dysplasia and following One Medicine concept, similar measures would benefit dogs. Moreover, animal models have long been used to better understand the different diseases’ mechanisms. Current research in animal models was addressed and the role of rabbit models in pathophysiologic studies and of the dog as a spontaneous animal model were highlighted, denoting the inexistence of rabbit functional models to investigate therapeutic approaches in hip MOA.

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Section: Main Textmentioning

confidence: 99%

Mechanical osteoarthritis of the hip in a one medicine concept: a narrative review

Tomé,

Alves-Pimenta,

Sargo

et al. 2023

BMC Vet Res

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Clinical manifestations, endoscopic findings and outcomes of tonsillar fossa foreign bodies in dogs: seven cases (2020‐2023)

Boot,

Petitpre,

Lamoureux

2024

J of Small Animal Practice

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ObjectivesClinical presentation and outcomes of dogs with tonsillar foreign bodies are not described in the literature. The objective of this case series is to describe the presence, clinical manifestations, endoscopic findings and outcomes of foreign bodies in the palatine tonsillar fossa of dogs.Materials and MethodsMedical records of dogs in which tonsillar fossa foreign bodies were removed by endoscopy between 2020 and 2023 at a referral centre were reviewed. Dogs were included if complete medical records were available.ResultsSeven dogs were included. Among all clinical signs reported, acute onset of throat clearing occurred in all dogs. Palatine tonsil enlargement and protrusion from the tonsillar fossa were observed in four of seven dogs. Foreign bodies were removed under endoscopic guidance in all dogs; a vegetal foreign body was found in all but one dog (6/7). Complete resolution of clinical signs was reported in the five dogs for which follow‐up information was available.Clinical SignificanceThe tonsillar fossa is a rare but possible location for foreign bodies in dogs and should be explored even in the absence of macroscopic lesions of the tonsils, since some dogs could have a normal palatine tonsil appearance. Acute throat clearing should raise the suspicion of tonsillar fossa foreign bodies. The prognosis appears good after removal.

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Prevalence of respiratory signs in dogs with chronic gastroenteropathy in a referral population in the United Kingdom: 42 cases (2020)

Salas García,

Atkinson,

McCann

et al. 2024

J of Small Animal Practice

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ObjectivesTo determine the prevalence of respiratory signs in a referral population of dogs with chronic gastroenteropathy in the United Kingdom, and to describe the epidemiology and clinical presentation of the affected dogs.Materials and MethodsRetrospective review of canine patients diagnosed with chronic gastroenteropathy in a referral centre in the United Kingdom. Data included signalment, gastrointestinal and respiratory signs, blood analysis results and, where present, diagnostic imaging techniques, endoscopy, videofluoroscopic swallow study, bronchoalveolar lavage results and treatment response. To be included, a follow‐up of a minimum of 3 months was required. Cases were excluded if there was no minimum diagnostic dataset, the aetiology of the respiratory signs was other than gastrointestinal disease or a non‐gastrointestinal systemic disease was the cause of the gastrointestinal signs.ResultsOne hundred and forty‐eight dogs were included and 42 (28.4%) had concurrent respiratory signs. Gagging (69%) and vomiting (52.4%) were the most common gastrointestinal signs, while coughing (50%), tachypnoea (33.3%) and reverse sneezing (30.9%) were the most common respiratory signs. Abdominal ultrasound was performed in 31 (73.8%) while CT scan was the most common modality for thoracic (62.5%) and head (21.9%) imaging. Endoscopic procedures included gastrointestinal (54.8%), bronchoscopy (19%) and rhinoscopy (23.8%). Dietary modification was the most common treatment (66.67%). Eleven dogs (26.2%) had a relapse of the respiratory signs during the follow‐up period, of which, nine (81.8%) had a concurrent relapse of the gastrointestinal signs.Clinical SignificanceConcurrent respiratory signs in dogs with chronic gastroenteropathy are frequent. A clinical improvement of these respiratory signs might be achieved during the therapeutic management of gastrointestinal disorders.

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A One Health review of aerodigestive disease in dogs

Cited by 4 publications

References 247 publications

Mechanical osteoarthritis of the hip in a one medicine concept: a narrative review

Mechanical osteoarthritis of the hip in a one medicine concept: a narrative review

Clinical manifestations, endoscopic findings and outcomes of tonsillar fossa foreign bodies in dogs: seven cases (2020‐2023)

Prevalence of respiratory signs in dogs with chronic gastroenteropathy in a referral population in the United Kingdom: 42 cases (2020)

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