A one-pot strategy for regioselective synthesis of 6-aryl-3-oxo-2,3-dihydropyridazine-4-carbohydrazides

Rimaz, Mehdi; Mousavi, Hossein

doi:10.3906/kim-1210-5

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…Furthermore, from the green chemistry point of view, one-pot reactions are recognized as a powerful tool in modern synthetic organic chemistry, which leads to a clear and tangible decrease in the consumption of reagents, auxiliaries, catalysts and or promoters, and solvents and consequently causes minimization of waste, energy, and time. 15 In this regard, and after obtaining the successful strategy for the reduction of nitroarenes, we decided to introduce a new one-pot two-step reductive Schotten–Baumann-type acetylation approach for the efficient and green synthesis of N -aryl acetamides from aromatic nitro compounds. To this purpose, in the second step of the mentioned one-pot organic transformation ( viz.…”

Section: Resultsmentioning

confidence: 99%

Ni^II-containing l-glutamic acid cross-linked chitosan anchored on Fe₃O₄/f-MWCNT: a sustainable catalyst for the green reduction and one-pot two-step reductive Schotten–Baumann-type acetylation of nitroarenes

Mousavi,

Zeynizadeh,

Hasanpour Galehban

2024

Nanoscale Adv.

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Section: Resultsmentioning

confidence: 99%

Ni^II-containing l-glutamic acid cross-linked chitosan anchored on Fe₃O₄/f-MWCNT: a sustainable catalyst for the green reduction and one-pot two-step reductive Schotten–Baumann-type acetylation of nitroarenes

Mousavi,

Zeynizadeh,

Hasanpour Galehban

2024

Nanoscale Adv.

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Green and efficient one-pot three-component synthesis of novel drug-like furo[2,3-d]pyrimidines as potential active site inhibitors and putative allosteric hotspots modulators of both SARS-CoV-2 MPro and PLPro

Mousavi

Zeynizadeh

Rimaz

2023

Bioorganic Chemistry

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Practical Three-Component Regioselective Synthesis of Drug-Like 3-Aryl(or heteroaryl)-5,6-dihydrobenzo[h]cinnolines as Potential Non-Covalent Multi-Targeting Inhibitors To Combat Neurodegenerative Diseases

Mousavi,

Rimaz,

Zeynizadeh

2024

ACS Chem. Neurosci.

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Neurodegenerative diseases (NDs) are one of the prominent health challenges facing contemporary society, and many efforts have been made to overcome and (or) control it. In this research paper, we described a practical one-pot two-step three-component reaction between 3,4-dihydronaphthalen-1(2H)one (1), aryl(or heteroaryl)glyoxal monohydrates (2a−h), and hydrazine monohydrate (NH 2 NH 2 •H 2 O) for the regioselective preparation of some 3-aryl(or heteroaryl)-5,6-dihydrobenzo[h]cinnoline derivatives (3a−h). After synthesis and characterization of the mentioned cinnolines (3a−h), the in silico multi-targeting inhibitory properties of these heterocyclic scaffolds have been investigated upon various Homo sapiens-type enzymes, including

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A one-pot strategy for regioselective synthesis of 6-aryl-3-oxo-2,3-dihydropyridazine-4-carbohydrazides

Cited by 3 publications

References 3 publications

Ni^II-containing l-glutamic acid cross-linked chitosan anchored on Fe₃O₄/f-MWCNT: a sustainable catalyst for the green reduction and one-pot two-step reductive Schotten–Baumann-type acetylation of nitroarenes

Ni^II-containing l-glutamic acid cross-linked chitosan anchored on Fe₃O₄/f-MWCNT: a sustainable catalyst for the green reduction and one-pot two-step reductive Schotten–Baumann-type acetylation of nitroarenes

Green and efficient one-pot three-component synthesis of novel drug-like furo[2,3-d]pyrimidines as potential active site inhibitors and putative allosteric hotspots modulators of both SARS-CoV-2 MPro and PLPro

Practical Three-Component Regioselective Synthesis of Drug-Like 3-Aryl(or heteroaryl)-5,6-dihydrobenzo[h]cinnolines as Potential Non-Covalent Multi-Targeting Inhibitors To Combat Neurodegenerative Diseases

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A one-pot strategy for regioselective synthesis of 6-aryl-3-oxo-2,3-dihydropyridazine-4-carbohydrazides

Cited by 3 publications

References 3 publications

NiII-containing l-glutamic acid cross-linked chitosan anchored on Fe3O4/f-MWCNT: a sustainable catalyst for the green reduction and one-pot two-step reductive Schotten–Baumann-type acetylation of nitroarenes

NiII-containing l-glutamic acid cross-linked chitosan anchored on Fe3O4/f-MWCNT: a sustainable catalyst for the green reduction and one-pot two-step reductive Schotten–Baumann-type acetylation of nitroarenes

Green and efficient one-pot three-component synthesis of novel drug-like furo[2,3-d]pyrimidines as potential active site inhibitors and putative allosteric hotspots modulators of both SARS-CoV-2 MPro and PLPro

Practical Three-Component Regioselective Synthesis of Drug-Like 3-Aryl(or heteroaryl)-5,6-dihydrobenzo[h]cinnolines as Potential Non-Covalent Multi-Targeting Inhibitors To Combat Neurodegenerative Diseases

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Ni^II-containing l-glutamic acid cross-linked chitosan anchored on Fe₃O₄/f-MWCNT: a sustainable catalyst for the green reduction and one-pot two-step reductive Schotten–Baumann-type acetylation of nitroarenes

Ni^II-containing l-glutamic acid cross-linked chitosan anchored on Fe₃O₄/f-MWCNT: a sustainable catalyst for the green reduction and one-pot two-step reductive Schotten–Baumann-type acetylation of nitroarenes