A one-step photocatalytic synthesis of 2-(trifluoromethyl)butyrolactones

Photocatalysis: a promising route for 21st century organic chemistry

“…TiO 2 59-67 and also other catalysts [67][68][69][70][71][72] have been applied to many conversions, generally in organic solvent, although a few syntheses were performed in water 63 or ethanol. 64…”

The first general method for α-trifluoromethylation of carboxylic acids using BrF3

“…Treatment with Raney nickel produced the desired 2-trifluoromethylbutyrolactone 8. 12 Similarly, dimethyl malonate 1a afforded the known dimethyl 2-trifluoromethylmalonate 4a. 13 Strong steric hindrance to the carbon a to the carboxylate moiety as in butyl neopentanoate 1b is responsible for low yields of the corresponding 1,1-bis(methyl sulfide) 2b (20%), but the reactions with BrF 3 and Raney nickel proceed as expected resulting in butyl 2-trifluoromethyl-a-t-butyl acetate 4b.…”

The Furan-2(5H)-ones: Recent Synthetic Methodologies and its Application in Total Synthesis of Natural Products

“…This ring system, known also as furanone or butenolide [1], occurs as structural subunits in a large number of natural products isolated from many sources including sponges and algas [2], animals [3], plants [4], butterflies [5] and others insects [6]. This ring system has also been the target of many synthesis due its potential pharmaceutical and industry proprieties [18], as intermediate in synthesis of antibodies, as selective catalysts [19], as dopants for ferroelectric liquid crystals [20] and as monomers for ring-opening polymerization to generate polyesters as potential piezo-electric material [21]. This ring system has also been the target of many synthesis due its potential pharmaceutical and industry proprieties [18], as intermediate in synthesis of antibodies, as selective catalysts [19], as dopants for ferroelectric liquid crystals [20] and as monomers for ring-opening polymerization to generate polyesters as potential piezo-electric material [21].…”