A one-step polyphenol-based functionalization strategy of dual-enhanced antibacterial and osteogenic surfaces

Chen, Xiao; Sun, Meizhou; Zhang, Lujiao; Hu, Yang; Yang, Zhiwei; Duan, Shun; Xu, Fu-Jian; Jing, Juehua

doi:10.1016/j.cej.2024.151792

Chemical Engineering Journal

2024

DOI: 10.1016/j.cej.2024.151792

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A one-step polyphenol-based functionalization strategy of dual-enhanced antibacterial and osteogenic surfaces

Xiao Chen,

Meizhou Sun,

Lujiao Zhang

et al.

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Cited by 5 publications

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Interface/Dipole Polarized Antibiotics‐Loaded Fe₃O₄/PB Nanoparticles for Non‐Invasive Therapy of Osteomyelitis Under Medical Microwave Irradiation

Jin,

Liu,

Wang

et al. 2024

Advanced Materials

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Due to their poor light penetration, photothermal therapy and photodynamic therapy are ineffective in treating deep tissue infections, such as osteomyelitis caused by Staphylococcus aureus (S. aureus). Here, a microwave (MW)‐responsive magnetic targeting composite system consisting of ferric oxide (Fe3O4)/Prussian blue (PB) nanoparticles, gentamicin (Gent), and biodegradable poly(lactic‐co‐glycolic acid) (PLGA) is reported. The PLGA/Fe3O4/PB/Gent complex is used in combination with MW thermal therapy (MTT), MW dynamic therapy (MDT), and chemotherapy (CT) to treat acute osteomyelitis infected with S. aureus‐infected. The powerful antibacterial effect of the PLGA/Fe3O4/PB/Gent is determined by the synergistic effects of heat and reactive oxygen species (ROS) generation by the Fe3O4/PB nanoparticles under MW irradiation and the effective release of Gent at the infection site via magnetic targeting. The antibacterial mechanism of the PLGA/Fe3O4/PB/Gent under MW irradiation is analyzed using bacterial transcriptome RNA sequencing. The MW heat and ROS reduce the activity of the protein transporters on the bacterial membrane, along with the transport of various ions and the acceleration of phosphate metabolism, which can lead to increased permeability of the bacterial membrane, damage the ribosome and DNA, and accompany the internal protein efflux of the bacteria, thus effectively killing the bacteria.

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Interface/Dipole Polarized Antibiotics‐Loaded Fe₃O₄/PB Nanoparticles for Non‐Invasive Therapy of Osteomyelitis Under Medical Microwave Irradiation

Jin,

Liu,

Wang

et al. 2024

Advanced Materials

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A Bacterial Capturing, Neural Network‐Like Carbon Nanotubes/Prussian Blue/Puerarin Nanocomposite for Microwave Treatment of Staphylococcus Aureus‐Infected Osteomyelitis

Jin,

Liu,

Wang

et al. 2024

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Staphylococcus aureus (S. aureus)‐infected osteomyelitis is a deep tissue infection that cannot be effectively treated with antibiotics. Microwave (MW) thermal therapy (MTT) and MW dynamic therapy (MDT) based on MW‐responsive materials are promising for the therapy of bacteria‐infected osteomyelitis occurring in deep tissues that cannot be effectively treated with antibiotics. In this work, the MW‐responsive system of carbon nanotubes (CNTs)/Prussian blue (PB)/puerarin (Pue) with stable network‐like structures is constructed. The PB is grown in situ on the CNTs, and its introduction not only reduces the aggregation of the network‐like structures of the CNTs, but the large specific surface area and mesoporous structure can also provide many active sites for the adsorption of oxygen and polar molecules. Pue is a natural anti‐inflammatory material that reduces inflammation at the infection site. The composite of the CNTs and PB avoids the skin effect and thus can improve dielectric and reflection losses. The MW thermal response of CNTs/PB/Pue is mainly due to the occurrence of reflection loss, dielectric loss, multiple reflections and scattering, interface polarization, and dipole polarization. In addition, under MW irradiation, the CNTs/PB/Pue can produce reactive oxygen species (ROS), such as singlet oxygen (1O2), hydroxyl radical (·OH).

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Different polysaccharide-enhanced probiotic and polyphenol dual-functional factor co-encapsulated microcapsules demonstrate acute colitis alleviation efficacy and food fortification

Sun,

Lv,

Wang

et al. 2024

Carbohydrate Polymers

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A one-step polyphenol-based functionalization strategy of dual-enhanced antibacterial and osteogenic surfaces

Cited by 5 publications

References 54 publications

Interface/Dipole Polarized Antibiotics‐Loaded Fe₃O₄/PB Nanoparticles for Non‐Invasive Therapy of Osteomyelitis Under Medical Microwave Irradiation

Interface/Dipole Polarized Antibiotics‐Loaded Fe₃O₄/PB Nanoparticles for Non‐Invasive Therapy of Osteomyelitis Under Medical Microwave Irradiation

A Bacterial Capturing, Neural Network‐Like Carbon Nanotubes/Prussian Blue/Puerarin Nanocomposite for Microwave Treatment of Staphylococcus Aureus‐Infected Osteomyelitis

Different polysaccharide-enhanced probiotic and polyphenol dual-functional factor co-encapsulated microcapsules demonstrate acute colitis alleviation efficacy and food fortification

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A one-step polyphenol-based functionalization strategy of dual-enhanced antibacterial and osteogenic surfaces

Cited by 5 publications

References 54 publications

Interface/Dipole Polarized Antibiotics‐Loaded Fe3O4/PB Nanoparticles for Non‐Invasive Therapy of Osteomyelitis Under Medical Microwave Irradiation

Interface/Dipole Polarized Antibiotics‐Loaded Fe3O4/PB Nanoparticles for Non‐Invasive Therapy of Osteomyelitis Under Medical Microwave Irradiation

A Bacterial Capturing, Neural Network‐Like Carbon Nanotubes/Prussian Blue/Puerarin Nanocomposite for Microwave Treatment of Staphylococcus Aureus‐Infected Osteomyelitis

Different polysaccharide-enhanced probiotic and polyphenol dual-functional factor co-encapsulated microcapsules demonstrate acute colitis alleviation efficacy and food fortification

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Product

Resources

About

Interface/Dipole Polarized Antibiotics‐Loaded Fe₃O₄/PB Nanoparticles for Non‐Invasive Therapy of Osteomyelitis Under Medical Microwave Irradiation

Interface/Dipole Polarized Antibiotics‐Loaded Fe₃O₄/PB Nanoparticles for Non‐Invasive Therapy of Osteomyelitis Under Medical Microwave Irradiation