A one-year prospective study of refractory status epilepticus in Modena, Italy

Costs and cost‐driving factors for acute treatment of adults with status epilepticus: A multicenter cohort study from Germany

“…The concept of SRSE was introduced a few years ago and requires an SE that continues or recurs ≥24 h after the onset of anesthetic therapy and includes those cases in which SE recurs on the reduction or withdrawal of anesthesia. Although the transition from nonrefractory to refractory SE may be minor, and merely indicates that a patient needs one additional intravenous AED to stop SE, the SRSE is, by definition, always characterized by the failure of initial anesthetic therapy to stop SE and by a duration of ventilation of >24 h. SRSE occurs in approximately 12–26% and RSE in 14–57% of all cases of SE . Our results of a relative prevalence of SRSE of 9.7% and of RSE of 50.1% are in line with the results of these studies.…”

Refractory and super-refractory status epilepticus in adults: a 9-year cohort study

“…Status epilepticus (SE) is a potentially severe neurological emergency, with an annual incidence in Europe of 10–16 per 100,000 population, carrying a risk of major morbidity and mortality . Its persistence despite first‐ and second‐line administration of antiepileptic drugs (AED), referred to as ‘refractory’ SE (RSE), occurs in 14–46% of cases . Super‐refractory SE (SRSE) was recently defined as a refractory episode continuing despite 24 h of general anaesthesia and has been reported to occur in 12–26% of SE and in 13–42% of RSE .…”

“…Its persistence despite first‐ and second‐line administration of antiepileptic drugs (AED), referred to as ‘refractory’ SE (RSE), occurs in 14–46% of cases . Super‐refractory SE (SRSE) was recently defined as a refractory episode continuing despite 24 h of general anaesthesia and has been reported to occur in 12–26% of SE and in 13–42% of RSE . Available estimations of both RSE and SRSE incidence primarily rely on retrospective studies conducted in intensive care units (ICUs) or in developing countries , with heterogeneous designs accounting for their variability.…”

The role of AMPA receptors and their antagonists in status epilepticus

“…SE has an incidence of about 10‐60 cases per 100 000/y. The overall mortality of SE was estimated at around 20% . Recently, Kortland et al published data concerning the costs due to SE in 3 different German University Hospitals.…”

“…The overall mortality of SE was estimated at around 20%. [2][3][4] Recently, Kortland et al 5 published data concerning the costs due to SE in 3 different German University Hospitals. They have studied 341 admissions in 316 patients.…”