A one‐year virological survey of acute lntussusception in childhood

Nicolas, J.C.; Ingrand, D.; Fortier, B; Bricout, F

doi:10.1002/jmv.1890090404

Cited by 90 publications

(48 citation statements)

References 5 publications

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“…Subsequent studies, in Australia and France, using less sensitive methods for identifying rotavirus, found evidence of rotavirus in 8% and 9% of intussusception cases, respectively. 16,17 Because these studies lacked control groups, it was impossible to determine the risk of intussusception attributable to wild-type rotavirus infection, if any. Available data are insufficient to determine the role of wild-type rotavirus as a cause of intussusception.…”

Section: Discussionmentioning

confidence: 99%

Intussusception Among Recipients of Rotavirus Vaccine: Reports to the Vaccine Adverse Event Reporting System

et al. 2001

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ABSTRACT. Background. Rotavirus vaccine was licensed on August 31, 1998, and subsequently recommended for routine use among infants. To assess rare adverse events, postlicensure surveillance was conducted.Objective. To describe the cases of intussusception among rotavirus vaccine recipients reported to the Vaccine Adverse Event Reporting System from October 1998 through December 1999. Setting and Participants. Infants vaccinated with rotavirus vaccine in the United States.Outcome Measures. Intussusception confirmed by radiology, surgery, or autopsy report with medical record documentation or confirmed by a primary health care provider.Results. There were 98 confirmed cases of intussusception after vaccination with rotavirus vaccine reported to the Vaccine Adverse Event Reporting System; 60 of these developed intussusception within 1 week after vaccination. Based on calculations using vaccine distribution data and intussusception incidence rates from 2 separate databases, an estimated 7 to 16 cases would have been expected to occur in the week after vaccination by chance alone.Conclusion. Using a passive surveillance system for vaccine adverse events, we observed at least a fourfold increase over the expected number of intussusception cases occurring within 1 week of receipt of rotavirus vaccine. Other studies were initiated to further define the relationship between rotavirus vaccine and intussusception. In light of these and other data, the rotavirus vaccine manufacturer voluntarily removed its product from the market, and the recommendation for routine use of rotavirus vaccine among US infants has been withdrawn. T he live, oral, rhesus-human rotavirus reassortant-tetravalent vaccine (RRV-TV) was licensed for use in the United States on August 31, 1998. It was subsequently recommended for routine use in infants in a 3-dose series given at 2, 4, and 6 months of age. 1,2 This recommendation was based on the morbidity and economic burden of severe dehydrating rotavirus gastroenteritis among infants and young children. 1 In prelicensure clinical trials, 5 cases of intussusception were noted among 10 054 vaccinees who had received 1 of 3 different formulations of rotavirus vaccine. Two of these 5 cases received RRV-TV. All 5 intussusception cases occurred after either dose 2 or 3. The cases occurred 6 to 51 days after rotavirus vaccination; 3 of these cases occurred on days 6 or 7. In contrast, 1 case of intussusception was noted among 4633 controls. 3 The difference in the proportion of children who developed intussusception in the vaccinated and unvaccinated groups was not statistically significant. Although there was insufficient evidence to conclude that the association between RRV-TV and intussusception was causal rather than temporal, intussusception was noted in the package insert, and postlicensure surveillance for intussusception was recommended by the Advisory Committee on Immunization Practices (ACIP). 1 Distribution of RRV-TV commenced in October 1998. After vaccine introduction, reports to the Vaccine ...

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Section: Discussionmentioning

confidence: 99%

Intussusception Among Recipients of Rotavirus Vaccine: Reports to the Vaccine Adverse Event Reporting System

et al. 2001

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“…Adenoviruses are an important cause of respiratory infection in infants and children and have been associated with a significant proportion of cases of IS (5,7,12,17). To discern the potential contribution of viral factors in the pathogenesis of IS, we studied the molecular epidemiology and genetic characterization of adenoviruses isolated from children with IS.…”

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confidence: 99%

Molecular Epidemiology of Adenovirus Isolates from Patients Diagnosed with Intussusception in Melbourne, Australia

Selvaraj¹,

Kirkwood

Bines

et al. 2006

J Clin Microbiol

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Twenty-one intussusception (IS)-associated and 59 temporally linked adenoviral isolates from clinical infections were compared. Species C (15/21 IS-and 32/59 non-IS-associated isolates) dominated. Of these, serotype 2 (AdV-2) (7/15 IS-associated isolates) and serotype 1 (AdV-1) (16/32 non-IS-associated isolates) were the most commonly identified serotypes. DNA restriction analysis of AdV-2 isolates identified six genomic types; of these, type D2 (3/7 IS-and 8/11 non-IS-associated isolates) was the dominant type after BamHI and SmaI digestion. IS-associated isolates are similar to circulating non-IS-associated strains.

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“…This observation was published by Konno, Suzuki, Kutsuzawa (my publication before 1982 was under the name of Kutsuzawa) et al in 1978 (34). However, two papers followed in 1982 reporting that only 8.3-9.3% of the cases with intussusception were associated with rotavirus infection (41,42). Both papers therefore failed to confirm the association between rotavirus infection and intussusception that we had observed.…”

Section: Rotavirus Infection and Intussusceptionmentioning

confidence: 72%

Rotavirus Infection and Intussusception: A View from Retrospect

Nakagomi

2000

Microbiology and Immunology

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A live orally-administrable rhesus rotavirus (RRV) tetravalent (TV) vaccine, licensed in the U.S.A. and the European Union, was recalled from the market because it was suspected to increase the risk of intussusception during the week following immunization. In contrast, natural rotavirus infection is generally believed not to cause intussusception. Because my experience contributed to the first paper that linked intussusception with rotavirus infection, I have re-examined our own data published 22 years ago and other studies on this issue. I also made a case study of adenovirus and intussusception as a paradigm to establish an etiological association of viral infection and intussusception. My hypothesis postulated in this review is that natural infection of susceptible (or predisposed) infants with some rotavirus strains, probably serotype G3 rotaviruses, will result in an appreciable fraction of idiopathic intussusception. Thus, the number of rotavirus-induced intussusception cases may change reflecting the relative frequency of G3 strains, which I believe was much higher in the 70s than during the last two decades. The epidemiological data indicate that the RRV-TV vaccine triggers intussusception at a rate significantly higher than the background incidence rate following the week of vaccination, particularly after the first dose. In contrast, the data do not suggest that the cumulative incidence among the vaccine recipients increases accordingly, implicating that the risk of intussusception attributable to the RRV-TV vaccine may be minimal.

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A one‐year virological survey of acute lntussusception in childhood

Abstract: A prospective study was carried out during 1 year in order to correlate intussusceptions in childhood with a viral infection. A virus was incriminated in 50% of the 64 patients in this survey. Adenovirus infections remain predominant as compared to rotavirus infections.

Cited by 90 publications

References 5 publications

Intussusception Among Recipients of Rotavirus Vaccine: Reports to the Vaccine Adverse Event Reporting System

Intussusception Among Recipients of Rotavirus Vaccine: Reports to the Vaccine Adverse Event Reporting System

Molecular Epidemiology of Adenovirus Isolates from Patients Diagnosed with Intussusception in Melbourne, Australia

Rotavirus Infection and Intussusception: A View from Retrospect

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