Gluteal compartment syndrome (GCS) is a rare form of acute compartment syndrome. There are some causes, such as prolonged periods of immobilization and traumatic or iatrogenic events. We report two cases of gluteal compartment syndrome after orthopedic surgical intervention for fracture stabilization. The patients were both hypocoagulated due to the presence of two mechanical heart valves. Despite early treatment, both patients remained with neurological deficits. Orthopedic and trauma surgeons must be aware of the possibility of gluteal compartment syndrome in perioperative patients. Recognizing and managing risk factors such as hypocoagulation is crucial for its prevention.