A pain reflex-inspired hydrogel for refractory wound healing

Guo, Chuan; Wang, Yu; Song, Haoyang; Li, Weilong; Kong, Qingquan; Wu, Ye

doi:10.1016/j.matdes.2022.110986

Cited by 11 publications

(5 citation statements)

References 41 publications

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“…This hydrogel also promoted collagen deposition, reduced the production of TNF-α, increased the interleukin 10 (IL-10) level, and promoted revascularization. 109 Based on the results of this study, chronic infected diabetic wounds could be treated with the developed hydrogel. However, in this study, the bioadhesive properties of the hydrogels on wet tissue were not assessed.…”

Section: Reviewmentioning

confidence: 96%

“…For example, ε-PL and oxidized hyaluronic acid (OHA) were utilized to engineer an antibacterial wound healing hydrogel via the Schiff base reaction between the amino groups of ε-PL and aldehyde groups of OHA within 10 s. 109 To impart anti-inflammatory and pro-angiogenic activity to the hydrogel, deferoxamine-loaded amino-functionalized mesoporous silica nanoparticles (MSNs-NH 2 @DFO) were also prepared and fixed into the hydrogel through Schiff base bonds (Fig. 3.)…”

Section: Chemically Crosslinked Polylysine-based Hydrogelsmentioning

confidence: 99%

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Antibacterial polylysine-containing hydrogels for hemostatic and wound healing applications: preparation methods, current advances and future perspectives

Pourshahrestani,

Zeimaran,

Fauzi

2024

Biomater. Sci.

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Section: Reviewmentioning

confidence: 96%

Section: Chemically Crosslinked Polylysine-based Hydrogelsmentioning

confidence: 99%

Antibacterial polylysine-containing hydrogels for hemostatic and wound healing applications: preparation methods, current advances and future perspectives

Pourshahrestani,

Zeimaran,

Fauzi

2024

Biomater. Sci.

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“…[19,20] Wu et al have developed HA-based hydrogels to treat chronically infected diabetic wounds and showed responsive to inflammatory microenvironment conditions. [21] Liu et al have prepared a skininspired gelatin/HA-based injectable remoistenable adhesive hydrogel for solving the insufficient adhesion to wet surfaces, and exhibited effective hemostasis and full-thickness dermal wound healing. [22] Wang et al have proposed the HA-metal hydrogels by mixing HA and metal ion solutions, especially HAÀ Cu hydrogel, which exhibited a significant antibacterial activity and promoted infectious wound healing.…”

Section: Introductionmentioning

confidence: 99%

“…Wu et al. have developed HA‐based hydrogels to treat chronically infected diabetic wounds and showed responsive to inflammatory microenvironment conditions [21] . Liu et al.…”

Section: Introductionmentioning

confidence: 99%

pH‐Responsive Calcium Ions and Crocetin Releasing Hydrogel for Accelerating Skin Wound Healing

Wang,

Ma,

Pan

et al. 2024

Chemistry An Asian Journal

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The ideal and highly anticipated dressing for skin wounds should provide a moist environment, possess antibacterial properties, and ensure sustained drug release. In the present work, a pH‐responsive hyaluronic acid‐based hydrogel (CPC@HA hydrogel) was formed by hydrogen bond and amido bond cross‐linking after introducing crocetin (Cro) and CaCO3@polyelectrolyte microspheres (CaCO3@PEM) to HA hydrogel to sustained, controlled release of the calcium ions and crocetin under slightly acid to accelerating skin wounds healing. The experiment results showed that the CPC@HA hydrogel exhibited porous network structures, stable physical properties, and had antibacterial properties and biocompatibility in vitro. In addition, the CPC@HA hydrogel covering on the skin wound could reduce inflammation and promote wound healing. The high expression of angiogenic cytokines (CD31) and epidermal terminal differentiation markers (Loricrin) of wound healing tissue suggested the CPC@HA hydrogel also had the function of promoting the remodeling of regenerated skin. Overall, CPC@HA hydrogel has promising potential for clinical applications in accelerated skin wound repair.

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“…Among them, hydrogels provide unique physiochemical properties, including relatively good mechanical stability, high liquid absorption, and insolubility, allowing versatile applications where biocompatibility and fabrication feasibility are critical [ 4 , 5 ]. Hydrogel layers have been commonly used as smart, pain-relieving wound patches [ 6 , 7 ], as well as precise structural scaffolds for cell culture and tissue engineering [ 8 , 9 ]. On the other hand, the responsive character of hydrogels, showing notable changes in their rheology, resistivity, or color tunability when exposed to variable external environments, make them a perfect tool for biosensing applications [ 10 , 11 ], including pH measurements.…”

Section: Introductionmentioning

confidence: 99%

3D Printed Hydrogel Sensor for Rapid Colorimetric Detection of Salivary pH

Łabowska,

Krakos,

Kubicki

2024

Sensors

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Salivary pH is one of the crucial biomarkers used for non-invasive diagnosis of intraoral diseases, as well as general health conditions. However, standard pH sensors are usually too bulky, expensive, and impractical for routine use outside laboratory settings. Herein, a miniature hydrogel sensor, which enables quick and simple colorimetric detection of pH level, is shown. The sensor structure was manufactured from non-toxic hydrogel ink and patterned in the form of a matrix with 5 mm × 5 mm × 1 mm individual sensing pads using a 3D printing technique (bioplotting). The authors’ ink composition, which contains sodium alginate, polyvinylpyrrolidone, and bromothymol blue indicator, enables repeatable and stable color response to different pH levels. The developed analysis software with an easy-to-use graphical user interface extracts the R(ed), G(reen), and B(lue) components of the color image of the hydrogel pads, and evaluates the pH value in a second. A calibration curve used for the analysis was obtained in a pH range of 3.5 to 9.0 using a laboratory pH meter as a reference. Validation of the sensor was performed on samples of artificial saliva for medical use and its mixtures with beverages of different pH values (lemon juice, coffee, black and green tea, bottled and tap water), and correct responses to acidic and alkaline solutions were observed. The matrix of square sensing pads used in this study provided multiple parallel responses for parametric tests, but the applied 3D printing method and ink composition enable easy adjustment of the shape of the sensing layer to other desired patterns and sizes. Additional mechanical tests of the hydrogel layers confirmed the relatively high quality and durability of the sensor structure. The solution presented here, comprising 3D printed hydrogel sensor pads, simple colorimetric detection, and graphical software for signal processing, opens the way to development of miniature and biocompatible diagnostic devices in the form of flexible, wearable, or intraoral sensors for prospective application in personalized medicine and point-of-care diagnosis.

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A pain reflex-inspired hydrogel for refractory wound healing

Cited by 11 publications

References 41 publications

Antibacterial polylysine-containing hydrogels for hemostatic and wound healing applications: preparation methods, current advances and future perspectives

Antibacterial polylysine-containing hydrogels for hemostatic and wound healing applications: preparation methods, current advances and future perspectives

pH‐Responsive Calcium Ions and Crocetin Releasing Hydrogel for Accelerating Skin Wound Healing

3D Printed Hydrogel Sensor for Rapid Colorimetric Detection of Salivary pH

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