A paleopathological case of pituitary tumor, Eagle’s syndrome and ossifying fibroma

Abstract

A paleopathological case of pituitary tumor, Eagle's syndrome and ossifying fibroma AbstrActThe salvage excavation in Mafraq region in Jordan uncovered a Byzantine female skull that died at an age of 18-25 years old. The visual and x-ray examination revealed diagnoses of pituitary adenoma, Eagle's syndrome, and maxillary ossifying fibroma. In addition, the case suffered a very poor oral health; dental caries, abscesses, and periodontal disease.

The first evidence of pituitary gland tumor in ground sloth Valgipes bucklandi Lund, 1839

“…Although some pathologies that could create that type of bone erosion do not leave distinguishing marks in the fossil record to aid in the differential diagnosis, a slowgrowing benign adenoma leaves some traces as clues, such as remodeled and irregular lesion edges (Marques, 2019) similar to what was observed (Figure 3 arrows). Also, the specific location of the alteration may only have been caused by pituitary growth, expanding the sella turcica, which is observed in literature (e.g., Al-Shorman, 2018;Canci et al, 1992;Hacking, 1995;Hawkins, 1992;Ortner, 2003;Ortner & Putschar, 1985). Other conditions that specifically caused this feature are unlikely, as they should cause marks on adjacent bones (Ortner, 2003).…”