A pan-cancer analysis of charged ubiquitin-specific protease 14's carcinogenic effects

Abstract

According to earlier research, the IDO1 protein is stabilized by overexpression of the ubiquitin-specific protease 14 (USP14), which increases tryptophan metabolism and T-cell failure. These results emphasize the function of USP14 in suppressing anti-tumor immunity and post-translational regulation in IDO1. USP14, however, does not have a Pan-cancer analysis. Using internet databases and R software, we looked at the possible oncogenic involvement of USP14 in 33 cancers using the TCGA and GEO datasets. We found fibroblast infiltration linked with malignancy in various cancers, including cervical squamous cell carcinoma, colon cancer, glioblastoma multiforme, and head and neck squamous cell carcinoma. The carcinogenic significance of USP14 in many malignancies is rather well understood because of the current pan-cancer investigation that we conducted.