A Pan-cancer Analysis of the Expression and Clinical Relevance of Small Nucleolar RNAs in Human Cancer

Gong, Jing; Li, Yajuan; Liu, Chun jie; Yu, Xiang; Li, Chunlai; Ye, Youqiong; Zhang, Zhao; Hawke, David H.; Park, Peter K.; Diao, Lixia; Putkey, John A.; Yang, Liuqing; Guo, An‐Yuan; Lin, Chunru; Han, Leng

doi:10.1016/j.celrep.2017.10.070

Cited by 211 publications

(224 citation statements)

References 53 publications

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“…In our study, we found the six-snoRNA signature expressed stably in serum, suggesting serum snoRNAs may serve as novel non-invasive biomarkers for ccRCC. 19 In this study, we found high expression of risky factors SNORD12B and SNORD93 Interestingly, according to the results of ROC and 3-D PCA, we found the six-snoRNA signature performance in tissue was better than that in serum.…”

Section: Discussionsupporting

confidence: 53%

“…19,32,33 Therefore, we evaluated relevance of CNV and these snoRNA expressions. is a key regulator of gene expression, and some snoRNAs were significantly associated with their CNVs in various cancers.…”

Section: The Snorna Methylation and Wnt Pathway Potentially Functiomentioning

confidence: 99%

“…19,34,35 Thus, we further evaluated the correlation of these snoRNAs with DNA methylation using snoRic database. 19,34,35 Thus, we further evaluated the correlation of these snoRNAs with DNA methylation using snoRic database.…”

Section: The Snorna Methylation and Wnt Pathway Potentially Functiomentioning

confidence: 99%

“…is a key regulator of gene expression, and some snoRNAs were significantly associated with their CNVs in various cancers. 19,32,33 Therefore, we evaluated relevance of CNV and these snoRNA expressions. The result showed that the expression levels of SNORA2, SNORD12B, SNORA70B, SNORD93 and SNORD116-2 were positively correlated with their CNVs in ccRCC, respectively ( Figure 5B).…”

Section: The Snorna Methylation and Wnt Pathway Potentially Functiomentioning

confidence: 99%

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Expression signature of six‐snoRNA serves as novel non‐invasive biomarker for diagnosis and prognosis prediction of renal clear cell carcinoma

Zhao

Yan

et al. 2020

J Cellular Molecular Medi

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Increasing evidence has verified that small nucleolar RNAs (snoRNAs) play significant roles in tumorigenesis and exhibit prognostic value in clinical practice. In the study, we analysed the expression profile and clinical relevance of snoRNAs from TCGA database including 530 ccRCC (clear cell renal cell carcinoma) and 72 control cases. By using univariate and multivariate Cox analysis, we established a six-snoRNA signature and divided patients into high-risk or low-risk groups. We found patients in highrisk group had significantly shorter overall survival and recurrence-free survival than those in low-risk group in test series, validation series and entire series by Kaplan-Meier analysis. We also confirmed this signature had a great accuracy and specificity in 64 clinical tissue cases and 50 serum samples. Then, depending on receiver operating characteristic curve analysis we found the six-snoRNA signature was an superior indicator better than conventional clinical factors (AUC = 0.732). Furthermore, combining the signature with TNM stage or Fuhrman grade were the optimal indicators (AUC = 0.792; AUC = 0.800) and processed the clinical applied value for ccRCC. Finally, we found the SNORA70B and its hose gene USP34 might directly regulate Wnt signalling pathway to promote tumorigenesis in ccRCC. In general, our study established a six-snoRNA signature as an independent and superior diagnosis and prognosis indicator for ccRCC. K E Y W O R D S biomarker, clear cell renal cell carcinoma, overall survival, prognostic, recurrence-free survival, snoRNAs S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section. How to cite this article: Zhao Y, Yan Y, Ma R, et al. Expression signature of six-snoRNA serves as novel non-invasive biomarker for diagnosis and prognosis prediction of renal clear cell carcinoma.

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Section: Discussionsupporting

confidence: 53%

Section: The Snorna Methylation and Wnt Pathway Potentially Functiomentioning

confidence: 99%

Section: The Snorna Methylation and Wnt Pathway Potentially Functiomentioning

confidence: 99%

Section: The Snorna Methylation and Wnt Pathway Potentially Functiomentioning

confidence: 99%

See 2 more Smart Citations

Expression signature of six‐snoRNA serves as novel non‐invasive biomarker for diagnosis and prognosis prediction of renal clear cell carcinoma

Zhao

Yan

et al. 2020

J Cellular Molecular Medi

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“…SnoRNAs could be regulated by their host genes, copy number variation, and DNA methylation . Some scientists pointed out that the host genes may affect the expression of snoRNAs by cotranscription; however, other scholars reported that the functions of some SNHG members were independent of their snoRNAs . Moreover, recent studies have shown that some snoRNAs are also related to cancer tumorigenesis .…”

Section: Small Nucleolar Host Genes and Snornasmentioning

confidence: 99%

Long non‐coding small nucleolar RNA host genes in digestive cancers

et al. 2019

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Although long noncoding RNAs (lncRNAs) do not have protein coding capacities, they are involved in the pathogenesis of many types of cancers, including hepatocellular carcinoma, cervical cancer, and gastric cancer. Notably, the roles of lncRNAs are vital in nearly every aspect of tumor biology. Long non‐coding small nucleolar RNA host genes (lnc‐SNHGs) are abnormally expressed in multiple cancers, including urologic neoplasms, respiratory tumors, and digestive cancers, and play vital roles in these cancers. These host genes could participate in tumorigenesis by regulating proliferation, migration, invasion and apoptosis of tumor cells. This review focuses on the overview of the roles that lnc‐SNHGs play in the formation and progression of digestive cancers.

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SNORA28 Promotes Proliferation and Radioresistance in Colorectal Cancer Cells through the STAT3 Pathway by Increasing H3K9 Acetylation in the LIFR Promoter

Liu,

Zhang,

Fan

et al. 2024

Advanced Science

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Radiotherapy is essential for treating colorectal cancer (CRC), especially in advanced rectal cancer. However, the low radiosensitivity of CRC cells greatly limits radiotherapy efficacy. Small nucleolar RNAs (snoRNAs) are a class of noncoding RNA that primarily direct post‐transcriptional modifications of ribosomal RNAs (rRNAs), small nuclear RNAs (snRNAs), and other cellular RNAs. While snoRNAs are involved in tumor progression and chemoresistance, their association with radiosensitivity remains largely unknown. Herein, SNORA28 is shown highly expressed in CRC and is positively associated with poor prognosis. Furthermore, SNORA28 overexpression enhances the growth and radioresistance of CRC cells in vitro and in vivo. Mechanistically, SNORA28 acts as a molecular decoy that recruits bromodomain‐containing protein 4 (BRD4), which increases the level of H3K9 acetylation at the LIFR promoter region. This stimulates LIFR transcription, which in turn triggers the JAK1/STAT3 pathway, enhancing the proliferation and radioresistance of CRC cells. Overall, these results highlight the ability of snoRNAs to regulate radiosensitivity in tumor cells and affect histone acetylation modification in the promoter region of target genes, thus broadening the current knowledge of snoRNA biological functions and the mechanism underlying target gene regulation.

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A Pan-cancer Analysis of the Expression and Clinical Relevance of Small Nucleolar RNAs in Human Cancer

Cited by 211 publications

References 53 publications

Expression signature of six‐snoRNA serves as novel non‐invasive biomarker for diagnosis and prognosis prediction of renal clear cell carcinoma

Expression signature of six‐snoRNA serves as novel non‐invasive biomarker for diagnosis and prognosis prediction of renal clear cell carcinoma

Long non‐coding small nucleolar RNA host genes in digestive cancers

SNORA28 Promotes Proliferation and Radioresistance in Colorectal Cancer Cells through the STAT3 Pathway by Increasing H3K9 Acetylation in the LIFR Promoter

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