A pan-cancer analysis revealed the role of the SLC16 family in cancer

Li, Jun; Xie, Jiaheng; Wu, Dan; Chen, Liang; Gong, Zixuan; Wu, Rui; Hu, Y.; Zhao, Jiangning; Xu, Yetao

doi:10.1080/19336950.2021.1965422

Cited by 23 publications

(25 citation statements)

References 59 publications

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“…Epigenetics exists in a wide range of organisms, and posttranscriptional modification is a common regulatory pathway. 27 M6A-methylation is the most common posttranscriptional modification in eukaryotes. 28 This process is mediated by methylase (writer), demethylase (eraser), and methylated reading protein (reader), and is involved in the homeostasis regulation of organisms and the occurrence and development of diseases.…”

Section: Discussionmentioning

confidence: 99%

A Novel Pyroptosis-Related lncRNA Signature for Predicting the Prognosis of Skin Cutaneous Melanoma

Xie¹,

Li²,

Liang³

et al. 2021

IJGM

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To construct a prognosis model of melanoma based on pyroptosis related genes. Methods: Melanoma RNA-sequencing data was downloaded from TCGA. First, the lnRNAs related to pyroptosis were obtained through Pearson correlation analysis. Then, the prognosis model of pyroptosis related genes was constructed by Cox regression and Lasso regression. Melanoma patients were divided into high-risk and low-risk groups by risk score, and the differences in prognosis and immune microenvironment between the two groups were explored. Results: We found that the high-risk group had a significantly poorer prognosis, and different groups differed in immune infiltration, m6A methylation, and immune checkpoint. Conclusion: Our prognostic model can provide a reference for the study of pyroptosis in melanoma cells and provide a new idea for melanoma treatment.

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Section: Discussionmentioning

confidence: 99%

A Novel Pyroptosis-Related lncRNA Signature for Predicting the Prognosis of Skin Cutaneous Melanoma

Xie¹,

Li²,

Liang³

et al. 2021

IJGM

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“…Six immune subtypes were identified according to different immune expression signatures of tumor, including C1 (wound healing), C2 (IFN-γ dominant), C3 (inflammatory), C4 (lymphocyte depleted), C5 (immunologically quiet), and C6 (TGF-β dominant) [ 13 ]. We also analyzed STK17B expression in different immune subtypes using TISIDB ( http://cis.hku.hk/TISIDB/index.php ) [ 14 , 15 ].…”

Section: Methodsmentioning

confidence: 99%

“…We also analyzed STK17B expression in different immune subtypes using TISIDB (http://cis.hku. hk/TISIDB/index.php) [14,15].…”

Section: Analysis Of Immune Infiltrationmentioning

confidence: 99%

Prognostic and immune-related value of STK17B in skin cutaneous melanoma

et al. 2022

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Skin cutaneous melanoma (SKCM) is a common cancer of which mortality is increasing continuously. Our study conducted a series of analyses on the clinical significance of Serine/threonine kinase 17B (STK17B) in SKCM to provide a new biomarker for diagnosis and treatment. The RNA-sequence data were obtained from The Cancer Genome Atlas and Genotype-Tissue Expression databases. The data of 468 SKCM patients were divided into STK17B high- and low-expression groups and analyzed by Bioconductor package to identify the differential expressed genes. The R package of “clusterProfiler” was used for Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and Gene-Set Enrichment Analysis analyses. A protein-protein interaction network and immune infiltration landscape were respectively constructed via STRING database and ssGSEA. STK17B had lower expression in SKCM than normal tissues. Besides, STK17B expression was significantly related to some clinicopathological characteristics in SKCM patients including T stage, Breslow depth, radiation therapy, melanoma Clark level, and pathologic stage. The Kaplan-Meier curve analyses revealed that the low expression of STK17B was correlated with poor overall survival and disease-specific survival. We constructed nomograms to predict the 1-, 3-, and 5-year survival of SKCM patients. The function enrichment analyses showed STK17B-related differential expressed genes were enriched in cellular differentiation and immune-related progress. STK17B expression level were positively correlated with infiltrating level of immune cells. In this study, we found that STK17B, which played an important role in immune infiltration, could be a new biomarker for diagnosis and prognosis in SKCM patients.

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“…The development of bioinformatics and related databases has made the exploration of tumor genomics more convenient and accurate ( Li et al, 2021 ). Among these databases, the TCGA and ICGC databases are the two most commonly used, since they contain a large amount of high-throughput sequencing data and related clinical information ( Cao et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Transcriptome Analysis of Solute Carrier-Associated Genes in Hepatocellular Carcinoma: Friend or Foe?

Wei

Ying

et al. 2022

Front. Genet.

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Hepatocellular carcinoma (HCC) is one of the most common types of cancer, and its treatment remains difficult. Since the early symptoms of HCC are not obvious, many HCC patients are already at an advanced stage of the disease at the time of diagnosis. Although current targeted therapy and immunotherapy have been initially effective in HCC patients, several patients have shown low response rates or developed drug resistance, which leads to tumor progression and even death. Hence, there is an urgent need for new biomarkers to guide the prognosis and treatment of HCC. In our study, a prognostic signature consisting of nine SLC genes was constructed in HCC by comprehensive analysis. By calculating risk scores, HCC patients could be divided into high-risk and low-risk groups, with the high-risk group having a significantly poorer prognosis. In addition, we found a hub gene, SLC7A11, which is a robust prognostic marker of HCC. In conclusion, our study can serve as a reference for the prognostic evaluation and treatment of HCC.

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A pan-cancer analysis revealed the role of the SLC16 family in cancer

Cited by 23 publications

References 59 publications

A Novel Pyroptosis-Related lncRNA Signature for Predicting the Prognosis of Skin Cutaneous Melanoma

A Novel Pyroptosis-Related lncRNA Signature for Predicting the Prognosis of Skin Cutaneous Melanoma

Prognostic and immune-related value of STK17B in skin cutaneous melanoma

Transcriptome Analysis of Solute Carrier-Associated Genes in Hepatocellular Carcinoma: Friend or Foe?

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