A paper-based colorimetric method for monitoring of lithium therapeutic levels

Sheikh, Mahsa; Qassem, Meha; Kyriacou, P. A.

doi:10.1039/d2ay01743a

Cited by 1 publication

(1 citation statement)

References 19 publications

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“…Conventional inductively coupled plasma mass spectrometry is high-precision but requires complicated operation and an ultraclean environment. Facile paper-based colorimetric determination based on Li + recognition molecules hardly yields a quantitative Li + concentration . So far, the study of Li + detection technology with both precision and convenience is valuable and meaningful for a wide range of practical applications.…”

Section: Introductionmentioning

confidence: 99%

Archaea-Inspired Switchable Nanochannels for On-Demand Lithium Detection by pH Activation

Liu,

Qian,

et al. 2024

ACS Cent. Sci.

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With the rapid development of the lithium ion battery industry, emerging lithium (Li) enrichment in nature has attracted ever-growing attention due to the biotoxicity of high Li levels. To date, fast lithium ion (Li + ) detection remains urgent but is limited by the selectivity, sensitivity, and stability of conventional technologies based on passive response processes. In nature, archaeal plasma membrane ion exchangers (NCLX_Mj) exhibit Li + -gated multi/monovalent ion transport behavior, activated by different stimuli. Inspired by NCLX_Mj, we design a pHcontrolled biomimetic Li + -responsive solid-state nanochannel system for on-demand Li + detection using 2-(2-hydroxyphenyl)benzoxazole (HPBO) units as Li + recognition groups. Pristine HPBO is not reactive to Li + , whereas negatively charged HPBO enables specific Li + coordination under alkaline conditions to decrease the ion exchange capacity of nanochannels. On-demand Li + detection is achieved by monitoring the decline in currents, thereby ensuring precise and stable Li + recognition (>0.1 mM) in the toxic range of Li + concentration (>1.5 mM) for human beings. This work provides a new approach to constructing Li + detection nanodevices and has potential for applications of Li-related industries and medical services.

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Section: Introductionmentioning

confidence: 99%