A Paper-Based Optical Sensor for the Screening of Viruses Through the Cysteine Residues of Their Surface Proteins: The Detection of Coronavirus Infection

Gholami, Mahnaz D.; Guppy-Coles, K.; Nihal, Serena; Langguth, Daman; Sonar, Prashant; Ayoko, Godwin A.; Punyadeera, Chamindie; Izake, Emad L.

doi:10.2139/ssrn.4057071

Cited by 1 publication

(1 citation statement)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5 Since stimuli-responsive materials adopt different behaviors depending on the conditions, desired properties can be programmed. As a result, stimuli-responsive materials hold considerable promise in applications ranging from disease detection 6 to sustainable building environment development. 7 Among the varying types of triggers, pH has attracted interest not only due to the ease of controllability but also the broad application potential.…”

Section: ■ Introductionmentioning

confidence: 99%

Soft Materials with Time-Programmed Changes in Physical Properties through Lyotropic Phase Transitions Induced by pH-Changing Reactions

Bowley,

Liu,

Adams

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

We present the development of time-programmable functional soft materials. The materials undergo reversible phase transitions between lyotropic phases with different topologies and symmetries, which in turn have very different physical properties: viscosity, diffusion, and optical transparency. Here, this behavior is achieved by combining pHresponsive lyotropic phases made from the lipid monoolein doped with 10% oleic acid, with chemical reactions that have well-defined controllable kinetics: autocatalytic urea−urease and methyl formate hydrolysis, which increase and decrease pH, respectively. In this case, we use small-angle X-ray scattering (SAXS) and optical imaging to show temporally controlled transitions between the cloudy hexagonal phase, which is a two-dimensional (2D) array of cylindrical inverse micelles, and the transparent, highly viscous three-dimensional (3D) bicontinuous cubic phases. By combining these into a single reaction mixture where the pH increases and then decreases again, we can induce a sequential transformation cycle from hexagonal to cubic and back to hexagonal over several hours. The sample therefore changes from cloudy to transparent and back again as a proof-of-concept demonstration for a wider range of soft materials with time-programmable changes in physical properties.

show abstract

Section: ■ Introductionmentioning

confidence: 99%