2004
DOI: 10.1088/0031-9155/49/18/006
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A parameter study to determine the optimal source neutron energy in boron neutron capture therapy of brain tumours

Abstract: The values of the parameters used in boron neutron capture therapy (BNCT) to calculate a given dose to human tissue vary with patients due to different physical, biological and/or medical circumstances. Parameters include the tissue dimensions, the 10B concentration and the relative biological effectiveness (RBE) factors for the different dose components associated with BNCT. Because there is still no worldwide agreement on RBE values, more often than not, average values for these parameters are used. It turns… Show more

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Cited by 5 publications
(2 citation statements)
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“…As the aim of this study is to compare doses induces by different epithermal energy neutron, the standard estimation of the biological dose using fixed RBE is considered as sufficient. The results obtained in this study can be compared to those obtained in [28], where RBE factors are examined as parameters influencing the optimal neutron source energy estimation. Our results are in agreement with the results presented in [28] : the use of neutron source in the range of 10 eV to few keV improves the capture reaction rate on 10 B and the optimal neutron energy for tumours seated at 4 cm from the skin is focused around 2 keV.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…As the aim of this study is to compare doses induces by different epithermal energy neutron, the standard estimation of the biological dose using fixed RBE is considered as sufficient. The results obtained in this study can be compared to those obtained in [28], where RBE factors are examined as parameters influencing the optimal neutron source energy estimation. Our results are in agreement with the results presented in [28] : the use of neutron source in the range of 10 eV to few keV improves the capture reaction rate on 10 B and the optimal neutron energy for tumours seated at 4 cm from the skin is focused around 2 keV.…”
Section: Discussionmentioning
confidence: 99%
“…The results obtained in this study can be compared to those obtained in [28], where RBE factors are examined as parameters influencing the optimal neutron source energy estimation. Our results are in agreement with the results presented in [28] : the use of neutron source in the range of 10 eV to few keV improves the capture reaction rate on 10 B and the optimal neutron energy for tumours seated at 4 cm from the skin is focused around 2 keV. Moreover, results presented in [29] indicate that neutrons with a few keV energy induce higher values of FoM, such as the TG considering the maximum biological dose in the brain.…”
Section: Discussionmentioning
confidence: 99%