New technological and scientific advances in the development of sensors and actuators demand the development of new devices to deal with recent problems and challenges in these new and emerging processes. Moreover, paper-based devices have tremendous potential for developing actuators as paper exhibits capillary transport and hygroexpansion due to swelling of the fibers when absorbing water. Therefore, this paper proposes a mini actuator that is based on a hygro-thermal-paper-based cantilever beam that is activated by means of a droplet of an aqueous solution in combination with a circulating electrical current to analyze its response. The contribution of this proposal includes the analysis of the flexural response of the mini actuator when it is tested by using two different solutions: distilled water and a water/alcohol solution. Additionally, four cases related to the droplet volume are studied and a statistical analysis of the bending responses is presented. The results achieved show that that water-alcohol solutions have a lower deviation in comparison with water only. Moreover, it is demonstrated that a specific change in the maximum displacement is obtained according to the volume and the type of solution. Thus, it is suggested that the response of the mini actuator can be tuned using different aqueous solutions.