A parietal memory network revealed by multiple MRI methods

Gilmore, Adrian W.; Nelson, Steven M.; McDermott, Kathleen B.

doi:10.1016/j.tics.2015.07.004

Cited by 228 publications

(266 citation statements)

References 86 publications

Supporting

Mentioning

232

Contrasting

Unclassified

Order By: Relevance

“…Our findings strongly support previous suggestions that these areas in the parietal memory network have a genuine role in memory representation (9). In line with previous evidence (11), a purely attentional account of PPC function (25) does not sufficiently explain our data, because posterior parietal regions showed increased activation over time and with every additional encounter with a location.…”

Section: Discussionsupporting

confidence: 80%

“…Moreover, GABAergic and glutamatergic signatures of memory exist in the PPC, which speak to its role in episodic memory (23). Together, these and other recent findings led to the proposal of a parietal memory network, which is anatomically distinct from the spatially adjacent default-mode network (9,24). This network increases its activity with stimulus repetition and represents familiarity.…”

Section: Discussionmentioning

confidence: 76%

“…A region that is currently receiving increased attention in memory research is the posterior parietal cortex (PPC) (9). Although many fMRI studies have shown activation of the PPC during memory tasks (10), it has only recently been confirmed that there is a genuine contribution of the PPC to episodic memory that goes beyond attentional processes (11).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Rapid and independent memory formation in the parietal cortex

Brodt

Pöhlchen

Flanagin

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

138

116

View full text Add to dashboard Cite

Previous evidence indicates that the brain stores memory in two complementary systems, allowing both rapid plasticity and stable representations at different sites. For memory to be established in a long-lasting neocortical store, many learning repetitions are considered necessary after initial encoding into hippocampal circuits. To elucidate the dynamics of hippocampal and neocortical contributions to the early phases of memory formation, we closely followed changes in human functional brain activity while volunteers navigated through two different, initially unknown virtual environments. In one condition, they were able to encode new information continuously about the spatial layout of the maze. In the control condition, no information could be learned because the layout changed constantly. Our results show that the posterior parietal cortex (PPC) encodes memories for spatial locations rapidly, beginning already with the first visit to a location and steadily increasing activity with each additional encounter. Hippocampal activity and connectivity between the PPC and hippocampus, on the other hand, are strongest during initial encoding, and both decline with additional encounters. Importantly, stronger PPC activity related to higher memory-based performance. Compared with the nonlearnable control condition, PPC activity in the learned environment remained elevated after a 24-h interval, indicating a stable change. Our findings reflect the rapid creation of a memory representation in the PPC, which belongs to a recently proposed parietal memory network. The emerging parietal representation is specific for individual episodes of experience, predicts behavior, and remains stable over offline periods, and must therefore hold a mnemonic function.long-term memory | posterior parietal cortex | precuneus | memory systems consolidation | virtual reality L earning enables adaptive and effective interaction with the environment based on past experience. How this essential capability of the brain to encode, store, and later retrieve new information is implemented on the systems level has been the focus of many studies. However, although there is consistent evidence that specific brain regions are involved in learning and memory, the interactions between these regions and their temporal dynamics remain unclear. For declarative memory, one influential model proposes complementary roles of the hippocampus and neocortex in supporting memory representations (1-3). It assumes that the highly plastic hippocampus serves as a fast learner, transiently storing newly encountered information. Later on, this information is gradually integrated into more stable neocortical networks (4).Many experiments in animals and humans have confirmed decreased hippocampal but increased neocortical contributions to memory retrieval with longer consolidation intervals (5-7). Concerning the time frame during which hippocampal independence of a memory is established, accounts diverge widely. In the case of patients with medial temporal lobe (MTL) dama...

show abstract

Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 76%

See 1 more Smart Citation

Rapid and independent memory formation in the parietal cortex

Brodt

Pöhlchen

Flanagin

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

138

116

View full text Add to dashboard Cite

show abstract

“…We were specifically interested in the processes associated with initial exposure to conceptually novel (or familiar) information, rather than the prolonged gradual acquisition of new knowledge that has been explored (Barron, Dolan, & Behrens, 2013;McClelland, 2013;Zeithamova, Dominick, & Preston, 2012;Kumaran, Summerfield, Hassabis, & Maguire, 2009;McClelland, McNaughton, & O'Reilly, 1995). 1 The Hebrew University, 2 New York University A straightforward account of conceptual novelty and familiarity processing would suggest that the two might be distinguished by the same neural processes as their experimental counterparts (e.g., Gilmore, Nelson, & McDermott, 2015;Kafkas & Montaldi, 2014). Briefly, novelty and familiarity can be represented as two ends of a monotonic continuum, with novelty inducing increased activity in the recently suggested "parietal memory network" and in additional cortical and subcortical regions (Gilmore et al, 2015;Tulving et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Distinct Neural Suppression and Encoding Effects for Conceptual Novelty and Familiarity

Reggev

Bein

Maril

2016

Journal of Cognitive Neuroscience

View full text Add to dashboard Cite

Like yin and yang, novelty and familiarity are typically described as separate-yet-complementary aspects of an experience, two ends of a single continuum. However, novelty and familiarity are also multifaceted. For instance, novelty can sometimes result in enhanced mnemonic performance, whereas at other times familiarity is better remembered. As previous investigations focused primarily on the experimental aspect of novelty, the mechanisms supporting conceptual novelty (the novel combination of two previously unrelated existing concepts) remain unclear. Importantly, conceptual novelty can be recognized as such only when compared with preexperimental familiar knowledge, regardless of experimental status. Here we applied a combined repetition suppression/subsequent memory fMRI paradigm, focusing on the conceptual aspect of novelty and familiarity as the subject matter. Conceptual novelty was characterized by sustained neural activity; familiarity, on the other hand, exhibited repetition effects in multiple cortical regions, a subset of which was modulated by successful encoding. Subsequent memory of novelty was associated only with activation differences in a distinct set of regions, including the hippocampus and medial cortical regions. These results suggest that conceptual novelty (a) does not (easily) trigger the repetition suppression phenomenon but requires sustained neural recruitment and (b) activates dedicated encoding mechanisms. Conceptual familiarity, in contrast, allows rapid neural processing that depends upon existing neural representations. Overall, these findings challenge the definition of novelty as a unitary concept. Furthermore, they bear important implications for research into the neural bases of knowledge representation and recognition memory.

show abstract

“…Additional evidence from neuroimaging studies has indicated that the precuneus is involved in visuo-spatial imagery, episodic memory retrieval, selfprocessing operations and consciousness (for a review see Cavanna and Trimble 2006). In addition, the precuneus has recently proposed to be part of the parietal memory network (PMN), which shows modulation in brain activation depending on how strongly a stimuli captures one's attention (Gilmore et al 2015). In light of this evidence the observed activation differences in the present study may be explained by differences in the degree to which external representations of health risk probabilities capture one's attention and are mentally integrated into internal subjective health risk perceptions.…”

Section: Figmentioning

confidence: 99%

The neural correlates of health risk perception in individuals with low and high numeracy

Vogel

Keller

Koschutnig

et al. 2016

ZDM Mathematics Education

View full text Add to dashboard Cite

overestimated health risks. A comparison of brain activation between the groups demonstrated that the high-numeracy group expressed larger brain engagement during the health risk condition in regions that are commonly associated with conflict monitoring, decision-making and emotional processing. These results provide initial evidence that individuals with high-numeracy engage regions of the brain to a different extent compared to individuals with low-numeracy.

show abstract

A parietal memory network revealed by multiple MRI methods

Cited by 228 publications

References 86 publications

Rapid and independent memory formation in the parietal cortex

Rapid and independent memory formation in the parietal cortex

Distinct Neural Suppression and Encoding Effects for Conceptual Novelty and Familiarity

The neural correlates of health risk perception in individuals with low and high numeracy

Contact Info

Product

Resources

About